Accelerated Intermittent Theta Burst Stimulation in Unipolar Versus Bipolar Depression
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Depressive Disorder
- Sponsor
- Mansoura University
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Comparison of severity of manic symptoms before and after treatment
- Status
- Not Yet Recruiting
- Last Updated
- last year
Overview
Brief Summary
The goal of this interventional study is to learn if accelerated Intermittent Theta Burst Stimulation can improve symptoms of 30 participants with Unipolar depression in higher manner than symptoms of 30 participants with bipolar depression
Detailed Description
We will apply stimulatory TMS protocol for participants with Unipolar depression and participants with bipolar depression using MagVenture MagPro R30 stimulator with the Cool-B65 coil
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age:18_65 years
- •Sex:male and female
- •Patients with Unipolar depression and bipolar depression diagnosis confirmed by SCID according to DSM5
- •No pharmacological change in the last 4 weeks before the beginning of the stimulantion cycle
- •Pharmacological resistance
Exclusion Criteria
- •Patients complaining of psychosis.Substance Use Disorder.current suicidal ideation.major medical and neurological disorder
- •Patients complaining of epilepsy
- •pregnancy and breastfeeding
- •peacemaker spinal or bladder stimulator
- •History of skull surgery and trauma
- •presence of metallic foreign body
Outcomes
Primary Outcomes
Comparison of severity of manic symptoms before and after treatment
Time Frame: One year for completion of the study
We will use Young Mania Rating Scale._Young Mania Rating Scale:assess severity of manic symptoms, clinician rated,\<=12(remission)13_19(minimal symptoms)20_25(mild mania)26_37(moderate mania)38_60 severe mania
Comparison of the severity of the patient's illness at the time of assessment relative to the clinician's past experience with patients who have the same diagnosis.
Time Frame: One year for completion of the study
We will use Clinical Global Impression Severity Scale._Clinical Global Impression Severity Scale:rate the severity of the patient's illness at the time of assessment relative to the clinician's past experience with patients who have the same diagnosis,1 normal not at all ill,2 borderline mentally ill,3 mildly ill,4 moderately ill,5 markedly ill,6 severely ill,7 extremely ill
Comparison of severity and impact of insomnia before and after treatment
Time Frame: One year for completion of the study
We will use Insomnia Severity Index scale._Insomnia Severity Index:assess the nature, severity and impact of insomnia,0_7(absence insomnia) 8_14(subthreshold insomnia)15_21(moderate insomnia)22_28(severe insomnia)
Comparison of depressive symptoms before and after treatment
Time Frame: One year for completion of the study
We will use Hamilton Depression Rating Scale._Hamilton Depression Rating Scale:assess the severity of depressive symptoms, clinician rated,0_7(normal range)8_16(mild severity)17_23(moderate severity)\>23(severe depression)