The Chronic Effects of L-Carnitine Tartrate Supplementation on Recovery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 82
- 试验地点
- 1
- 主要终点
- Changes in Blood Markers of Muscle Damage
研究概览
简要总结
This study investigated the effects of CarnipureTM, a high-quality L-carnitine ingredient, on long term (5 weeks) recovery, muscle damage, and SOD status in a population of males and females while training two days per week. The primary outcomes defining recovery were changes in serum creatine kinase levels and perceptual changes in recovery. Supporting variables included an assessment of strength and power as a functional indicator of recovery. This study would be the first to examine the effects of CarnipureTM on long-term recovery. Our primary hypothesis was that L-carnitine supplementation would reduce muscle damage and improve perceptual measures of recovery. Our secondary hypotheses were that L-carnitine supplementation would better sustain strength and power and elevate SOD status.
详细描述
This study investigated the effects of CarnipureTM, a high-quality L-carnitine ingredient, on long term (5 weeks) recovery, muscle damage, and SOD status in a population of males and females while training two days per week. The primary outcomes defining recovery were changes in serum creatine kinase levels and perceptual changes in recovery. Supporting variables included an assessment of strength and power as a functional indicator of recovery. This study would be the first to examine the effects of CarnipureTM on long-term recovery. Our primary hypothesis was that L-carnitine supplementation would reduce muscle damage and improve perceptual measures of recovery. Our secondary hypotheses were that L-carnitine supplementation would better sustain strength and power and elevate SOD status.
In totality, the study will last 5-weeks, consisting of supplementation with maintenance exercise performed 2 days per week, at home. Week 5 will consist of a pre-training assessment, an intense lower-body strength endurance training day, and subsequent testing 48-hour testing (Post-Week 5). The baseline testing (will be performed on approximately 10 subjects per day over the course of 4 days) and will consist of the following measures:
- DEXA (Dual Energy X-ray Absorptiometry) Body Composition Analysis
- Blood Draw
- Salivary Measures
- Isometric Mid Thigh Pull
- Force Plate Mechanography
- Visual Analog Scales
For the first 4 weeks of training, participants will be asked to workout 2 days per week at home.
On Monday of week five, 20 subjects will be assessed on the following measures:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participation in at least 30 minutes of moderate activity exercise 3 times per week
排除标准
- •Body-mass index (BMI) of ≥ 30 kg/m²;
- •Cardiovascular, metabolic, endocrine, or thyroid disease
- •Smoking tobacco
- •Drinking alcohol (>7 or >14 drinks per week for women and men, respectively)
- •Pregnancy
- •Hypertension
- •Hyperlipidemia
- •Hyperglycemia
- •Thyroid disease
- •Metabolic disease
- •Type I or Type II Diabetes
- •Use of anabolic-androgenic steroids
- •Use of antioxidant supplements, NSAIDS, or nutritional supplements known to stimulate recovery or muscle mass gains, heart disease, prescription medications, dietary supplements that enhance muscle strength or muscle recovery
研究组 & 干预措施
Placebo Group
Participants will engage in a 5-week, whole-body, resistance training program 2 days per week will consuming a visually identical placebo (25mg hydroxypropyl methylcellulose) 30 minutes prior to exercise on training days or with the first meal of the day on non-training days. For week 5 of the study, participants will come in for 1 intense exercise training day.
干预措施: Resistance Training (Other)
Experimental Group
Participants will engage in a 5-week, whole-body, resistance training program 2 days per week will consuming a treatment condition (Carnipure™) 30 minutes prior to exercise on training days or with the first meal of the day on non-training days. For week 5 of the study, participants will come in for 1 intense exercise training day.
干预措施: Carnipure (Dietary Supplement)
Experimental Group
Participants will engage in a 5-week, whole-body, resistance training program 2 days per week will consuming a treatment condition (Carnipure™) 30 minutes prior to exercise on training days or with the first meal of the day on non-training days. For week 5 of the study, participants will come in for 1 intense exercise training day.
干预措施: Resistance Training (Other)
结局指标
主要结局
Changes in Blood Markers of Muscle Damage
时间窗: Baseline, Week 5, Post-Week 5
Experimental outcome examining blood protein concentrations in fasted whole blood samples.This outcome will be analyzed for the entire study population and will be analyzed as a sub-analysis in females only.
- Changes in subjective recovery scale that is directly related to recovery and inversely related to soreness.
时间窗: Immediately prior to every resistance training session throughout the study.
Assessed through a visual analog scale numbered 0-10 with visual descriptors. This outcome will be analyzed for the entire study population and will be analyzed as a sub-analysis in females only.
次要结局
- Changes in Muscle Power(Baseline, Week 5, Post-Week 5)
- Changes in Salivary Immunoglobulin A(Baseline, Week 5, Post-Week 5)
- Changes in Body Composition(Baseline, Post-Week 5)
- Changes in Superoxide Dismutase (SOD)(Baseline, Week 5, Post-Week 5)
- Changes in Muscle Strength(Baseline, Week 5, Post-Week 5)