临床试验/NCT02827227

NCT02827227已完成不适用

Values of the Immune Activation Markers CD38 and HLA-DR and the Ratio CD4/CD8 According to the Delay of Combined AntiRetroviral Therapy (c-ART) Initiation in Primary HIV-infected Patients (PRIMIMMUNO)

Hospices Civils de Lyon1 个研究点分布在 1 个国家目标入组 99 人开始时间: 2014年1月最近更新: 2016年7月12日

适应症

试验速览

阶段: 不适用
状态: 已完成
发起方: Hospices Civils de Lyon
入组人数: 99
试验地点: 1
主要终点: percentage of CD4+ and CD8+ T lymphocytes with activation markers (CD38 + and HLA-DR)

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

The objective was to identify factors associated with the normalization of the CD4/CD8 ratio (>=1) in patients with a history of primary HIV infection (PHI) and long-term combined antiretroviral therapy (cART).

研究设计

研究类型: Observational
观察模型: Cohort
时间视角: Prospective

入排标准

年龄范围: 18 Years 至 —（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•all HIV patients with a known history of PHI and a minimum of 2 years of effective cART (< 200 copies/mL) without interruption or virological failure

排除标准

•Patients with hepatitis C or B virus co-infection or with a history of neoplasia or immunosuppressive therapy after the date of PIH

结局指标

主要结局

percentage of CD4+ and CD8+ T lymphocytes with activation markers (CD38 + and HLA-DR)

时间窗: Day 0

percentage of CD4+ and CD8+ T lymphocytes with activation markers (CD38 + and HLA-DR) according to the delay of cART initiation (early 3 months or delayed \> 3 months).

次要结局

未报告次要终点

研究者

发起方

Hospices Civils de Lyon

申办方类型

Other

责任方

Sponsor

研究点 (1)

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