Mouse Allergen and Asthma Intervention Trial

Phase 3

Completed

• Conditions: Asthma; Mouse Allergy; Mouse Allergen Exposure
• Interventions: Other: Integrated Pest Management; Other: Education

• Registration Number: NCT01251224
• Lead Sponsor: Johns Hopkins University

Brief Summary

The MAAIT is a randomized, controlled trial of a home intervention to reduce mouse allergen exposure in mouse allergic children with asthma and mouse allergen exposure. Participants will be randomized to either the Integrated Pest Management (IPM) Group or the Education Group. The IPM Group will receive professional mouse abatement, education, two HEPA filters, allergen-proof mattress and pillow encasements, and targeted cleaning. The Education Group will receive education about IPM at the beginning of the trial and then after completion of the trial, will receive the IPM intervention. Participants will be followed for 12 months.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-11
• Study First Submitted: 2010-11-29
• Study First Submitted QC: 2010-11-30
• Study First Posted: 2010-12-01
• Primary Completion: 2016-09
• Study Completion: 2016-09
• Status Verified: 2017-03
• Last Update Submitted: 2017-03-15
• Last Update Posted: 2017-03-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 361

Inclusion Criteria

• persistent asthma
• exacerbation, previous 12 months
• evidence of mouse sensitization
• high levels of mouse allergen in home
• ages 5-17 years

Exclusion Criteria

• intermittent asthma
• no exacerbation in previous 12 months
• not sensitized to mouse
• low or undetectable mouse allergen in home
• other lung disease aside from asthma

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
IPM Group	Integrated Pest Management	This group will receive the full IPM intervention at baseline.
Education Group	Education	This group will receive IPM education at baseline, and then the full IPM intervention after completing the study.

Primary Outcome Measures

Name	Time	Method
change in asthma symptoms	0, 3, 6, 9, 12 months	days of asthma symptoms

Trial Locations

Locations (2)

Boston Children's; 🇺🇸 Boston, Massachusetts, United States

Johns Hopkins; 🇺🇸 Baltimore, Maryland, United States