Phenotyping the Chronic Respiratory Diseases (CRD) in Ho Chi Minh City, Vietnam
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 610
- 试验地点
- 1
- 主要终点
- Relative prevalence of the different chronic respiratory diseases phenotype
研究概览
简要总结
World Health Organization (WHO) considers chronic respiratory disease (CRD) as one of its four priorities. These diseases include asthma and rhinitis, chronic obstructive pulmonary diseases (COPD), occupational lung diseases, sleep apnoea syndromes, pulmonary hypertension, bronchiectasis and interstitial lung diseases. They constitute a serious public health problem in all countries throughout the world, in particular in low and middle income countries and in deprived populations. Hundreds of millions of people of all ages, in all countries of the world, are affected by chronic respiratory diseases. More than 50% of them live in low and middle income countries. Over 90% of deaths and the complete inability, due to CRDs occur in countries with low or middle incomes.
The main causes of CRD are: tobacco smoke, occupational factors, indoor air pollution and outdoor air pollution, allergens, sequelae of respiratory infections such as tuberculosis.
More than 30% of the population of Ho Chi Minh City (HCMC) could develop a CRD. In fact, 15% of children and 7% of adults could become asthma and 6% of the population could become COPD due to smoking. Children exposed to fumes from biomass burning, early in their life, seem to have a higher risk to develop COPD. The high level of air pollution in HCMC could aggravate asthma / COPD. Populations combining the rural risk (exposure to smoke from biomass) and the urban risk (smoking, pollution) may develop COPD much earlier (before age 40). Among the 9 million people in HCMC, 50% of the population is rural origin. Within this population, parasites could play a protective role against the risk of allergic asthma and consequently, the better control of helminthiasis among urban population, may result in allergic diseases such as asthma and anaphylaxis. Finally, the sequelae of tuberculosis (incidence is 200/100000) could participate to the morbidity of COPD / CRD.
Study granted by the ARES-CUD ("Comission universitaire au développement")
研究设计
- 研究类型
- Observational
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age: ≥ 18 years old
- •Gender: Female and Male
- •Signed informed consent
- •Out-patients at the Pham Ngoc Thach Hospital
- •One or several symptoms suggesting chronic respiratory disease (cough, chest tightness, wheezing, dyspnoea, sputum), lasting 3 months or more.
- •Lung function defect (FEV1/FVC < 0,7 or FEV1 < 80% PV with FEV1/FVC > 0,7 or FEV1> 80% PV and FEV1/FVC > 0,7 with a decrease of DLCO (< 80% PV).
- •FEV1: Forced Expiratory Volume in 1 Second FVC : Forced Vital Capacity PV: predicted value DLCO: Diffusing Capacity of the Lung for Carbon Monoxide
- •Patients are able to stop anti-histamine 5 days before evaluation.
- •Patients are able to stop bronchodilator treatment before performing lung function test according to standard practice (immediate release theophylline: 24 hours, long acting β2-agonist: 12 hours, short acting β2-agonist: 6 hours and short acting anticholinergic: 8 hours).
排除标准
- •The patients do not agree to participate in the study.
- •Presence of one or more chronic diseases: HIV, active tuberculosis, hypertension, heart failure, diabetes, low BMI (<18.5) or mental health disorders.
- •Treatment with B-blockers, drugs of vascular/heart disease
结局指标
主要结局
Relative prevalence of the different chronic respiratory diseases phenotype
时间窗: 4 months after start of study
This will be measured by the percentage of each chronic respiratory diseases phenotype, according to the lung function test.
次要结局
- Biomarkers assessment for risk factors of chronic respiratory diseases(4 months after start of study)
- role of environmental risk factors in developing chronic respiratory diseases(4 months after start of study)
- Induced sputum analysis to assess the relationship between phenotype and endotype among a sub-group of chronic respiratory diseases(4 months after start of study)
- role of occupational risk factors in developing chronic respiratory diseases(4 months after start of study)
- role of clinical risk factors in developing chronic respiratory diseases(4 months after start of study)
- Allergen skin reactivity test to assess the role of atopic in developing chronic respiratory diseases(4 months after start of study)
研究者
Olivier Michel
Head of clinic
Brugmann University Hospital