The Genetics Behind Vitamin D Status (VitDgen)

Not Applicable

Completed

• Conditions: Vitamin D Deficiency
• Interventions: Genetic: VitDgen

• Registration Number: NCT01741233
• Lead Sponsor: Technical University of Denmark

Brief Summary

The overall purpose of the study is to investigate whether there is a relationship between 26 different single nucleotide polymorphisms (SNPs) in the vitamin D pathway, ultraviolet B (UV-B) irradiation of the skin and vitamin D status.

The hypothesis is that vitamin D status are influated by different genetic genotypes in the vitamin D pathway.

Detailed Description

In this study approximately 80 participants (over 18 years) are included. All the participants has previously participated in the VitmaD intervention study (NCT01184716) .

Participants will in total receive 4 times UV-B irradiation (3 SED) with two day apart each time, to stimulate vitamin D production in the skin. The participants skintype will be measured. The study starts in January 2013 and runs to the end of Marts 2013. During this winter period, it is in Denmark not possible to produce vitamin D in the skin through sunlight exposure.

Study Timeline

• Study Start: 2012-11
• Study First Submitted: 2012-11-30
• Study First Submitted QC: 2012-11-30
• Status Verified: 2012-12
• Study First Posted: 2012-12-04
• Primary Completion: 2013-03
• Study Completion: 2013-03
• Last Update Submitted: 2013-07-31
• Last Update Posted: 2013-08-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 102

Inclusion Criteria

• Health participants over 18 years, that previously participated in VitmaD intervention study

Exclusion Criteria

• skindiseases
• intake of medicin that causes photosensitive skin
• pregnant or nursing
• sun vacation 3 month before the intervention
• intake of vitamin D supplement 3 month before the intervention

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
UV-B irraditation	VitDgen	VitDgen

Primary Outcome Measures

Name	Time	Method
serum 25-hydroxyvitamin D	10 days	Measures the vitamin D status i serum at baseline and at the end of the project

Secondary Outcome Measures

Name	Time	Method
Skintest	10 days	Optimize scientific; measures pigmentation and redness of the skin. Are measured at baseline and at end of project

Trial Locations

Locations (2)

DTU / National Food Institute; 🇩🇰 Morkhoj, Søborg, Denmark

Bispebjerg Hospital; 🇩🇰 Bispebjerg, Copenhagen, Denmark