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临床试验/NCT04969055
NCT04969055Unknown不适用

Prevalence, Clinical Features and Risk Factors of Cirrhotic Cardiomyopathy Assessed by Two-dimensional Speckle Tracking Imaging

Qilu Hospital of Shandong University1 个研究点 分布在 1 个国家目标入组 200 人开始时间: 2020年11月1日最近更新:
适应症

试验速览

阶段
不适用
入组人数
200
试验地点
1
主要终点
cirrhotic cardiomyopathy

研究概览

简要总结

The purpose of this study is to assess the prevalence of cirrhotic cardiomyopathy in patients with cirrhosis, and to analyze the correlation between the severity of cirrhosis and cardiac dysfunction. To investigate the risk factors for cirrhotic cardiomyopathy, and raise clinicians' awareness of cirrhotic cardiomyopathy, early assessment and intervention to improve long-term outcomes in patients with cirrhosis.

详细描述

Liver cirrhosis is the terminal stage of the development of chronic liver disease caused by various reasons, and it is often accompanied by multiple complications. Late cirrhosis is often accompanied by obvious changes in liver and systemic hemodynamics. Patients with liver cirrhosis are in a highly dynamic cycle Status: lower arterial blood pressure, increased heart rate, increased cardiac output, peripheral vascular resistance, which often lead to changes in myocardial structure and function, called cirrhotic cardiomyopathy. Cirrhotic cardiomyopathy (CCM) is defined as cardiac dysfunction in patients with end-stage liver disease in the absence of prior heart disease. The true burden of CCM among patients with ESLD is currently unknown. Prior studies evaluated CCM prevalence and estimated it to be approximately 50%, however, this estimate was based on the old criteria. In 2020, the Cirrhotic Cardiomyopathy Association updated the diagnostic criteria for cirrhotic cardiomyopathy. At present, the true prevalence of cirrhotic cardiomyopathy still needs to be reassessed. In addition, studies on the risk factors for cirrhotic cardiomyopathy are rare. Based on the above research background, carry out this research.

研究设计

研究类型
Observational
观察模型
Other
时间视角
Prospective

入排标准

年龄范围
18 Years 至 75 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • The clear diagnosis of cirrhosis in patients caused by various reasons

排除标准

  • History of cardiovascular disease
  • High blood pressure
  • Hepatocellular carcinoma (HCC) or other malignant tumors
  • Patients with the chronic obstructive pulmonary disease
  • Thyroid diseases
  • Severe infection in the last 2 weeks
  • History of liver transplantation and/or TIPS surgery
  • Presence of stage 3 or above chronic kidney disease or acute chronic kidney disease
  • Pregnant women
  • Did not sign the informed consent form and refused to participate

结局指标

主要结局

cirrhotic cardiomyopathy

时间窗: Within 48 hours after hospitalization

Different levels of left ventricular diastolic dysfunction in patients with liver cirrhosis

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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