Treatment of Mirizzi Syndrome

Completed

• Conditions: Acute Cholecystitis; Mirizzi Syndrome; Cholelithiasis

• Registration Number: NCT04672902
• Lead Sponsor: Tecnologico de Monterrey

Brief Summary

Mirizzi syndrome is an infrequent complication of long-standing cholelithiasis. Extrinsic compression of the common hepatic duct is usually caused by an impacted stone in Hartmann's pouch or cystic duct resulting in the development of cholecystobiliary fistula. This syndrome is classified based on the presence and severity of cholecystobiliary fistula. Mirizzi syndrome is challenging to diagnose preoperatively and may require complex biliary surgical procedures for resolution. Endoscopic treatment is a safe alternative with a high success rate. Single-operator cholangioscopy combined with lithotripsy has been shown to have a 90-100% success rate in the treatment of biliary stones. Herein, A single center experience treating Mirizzi syndrome with single-operator cholangioscopy guided electrohydraulic lithotripsy is presented. Difficult management of Mirizzi syndrome has led to research of new treatment options to minimize the risk of high rate complications. Single-operator cholangioscopy in combination with laser lithotripsy is an adequate and safe alternative for the treatment of this condition.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-11-01
• Status Verified: 2020-12
• Primary Completion: 2020-12-01
• Study Completion: 2020-12-01
• Study First Submitted: 2020-12-09
• Study First Submitted QC: 2020-12-15
• Last Update Submitted: 2020-12-15
• Study First Posted: 2020-12-17
• Last Update Posted: 2020-12-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 3

Inclusion Criteria

• Patients older than 18 years old
• Patients with a preoperative diagnosis of Mirizzi Syndrome
• Patients with a common bile duct dilatation

Exclusion Criteria

• Patients younger than 18 years old
• Patients with an inconclusive biliary diagnosis
• Patients without a diagnosis of Mirrizi Syndrome
• Patients without common bile duct dilatation

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Resolution of the common bile duct compression by an extrinsic gallbladder stone, with minimally invasive procedure such as single operator cholangioscopy, combined with lithotripsy	2019-2020	Single operator cholangioscopy, combined with lithotripsy, will be use for treating patients with Mirizzi syndrome, while avoiding open surgery, and subsequent lesions to the biliary ducts. Post surgical morbidity will be assessed.

Trial Locations

Locations (1)

Escuela Nacional de Medicina, Tecnologico de Monterrey; 🇲🇽 Monterrey, Nuevo Leon, Mexico