Comparision of two muscle relaxants, atracurium and rocuronium in children which are used for intubation in general anaesthesia
- Conditions
- Health Condition 1: - Health Condition 2: - Health Condition 3: - Health Condition 4: O- Medical and Surgical
- Registration Number
- CTRI/2021/10/037489
- Lead Sponsor
- Adesh Institute of Medical Sciences and Reaesrch
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Patients aged 1- 12 yrs of both the sexes, undergoing elective surgeries of average duration half to two hours, under general anaesthesia with ASA grade I-II and Mallampati class I&II will be included in the study.
1.Patients refusing to give informed consent.
2.Patients having major cardiovascular, pulmonary, hepatic, renal and neuromuscular diseases.
3.Allergic to any study drug.
4.Patients taking medications which interfere with NMBs - calcium channel blockers, B-blockers, steroids, anticonvulsants, frusemide, polypeptide antibiotics or aminoglycosides
5.Those with diseases affecting neuromuscular transmission (myopathies) or family history of neuromuscular disease.
6.Overweight patients.
7.Children coming for emergency operations.
8.Patients with anticipated difficult intubation (Mallampati score III and more).
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method We will compare the onset of action of the NMB between the two groups. <br/ ><br>We will compare the intubating conditions and intubation time of the two groups. <br/ ><br>We will also evaluate extubation time and recovery between the two groups. <br/ ><br>We will monitor and compare the hemodynamic changes and complications between the two groups. <br/ ><br>Timepoint: Hemodynamic variables are monitored before induction (baseline), after induction, after injection of NMB and before endotracheal intubation, just after intubation and then every 5 minutes for 30min after intubation, then every 15 mintutes afterwards till extubation and complete recovery <br/ ><br>Calibration of the relaxogram will be performed using supramaximal stimulation delivered in train-of-four (TOF) every 20 seconds (starts from induction of anesthesia till extubation of patient. <br/ ><br> <br/ ><br>
- Secondary Outcome Measures
Name Time Method To compare the efficacy and safety of neuromuscular blocker, rocuronium versus atracurium at a dose 2 x (ED95) for elective surgeries under general anaesthesia in paediatric patientsTimepoint: Hemodynamic variables are monitored before induction (baseline), after induction, after injection of NMB and before endotracheal intubation, just after intubation and then every 5 minutes for 30min after intubation, then every 15 mintutes afterwards till extubation and complete recovery <br/ ><br>Calibration of the relaxogram will be performed using supramaximal stimulation delivered in train-of-four (TOF) every 20 seconds (starts from induction of anesthesia till extubation of patient. <br/ ><br> <br/ ><br>