Evaluation of the effect of fractional carbon dioxide laser with platelet-rich plasma in the treatment of burn scars

Phase 3

Recruiting

Conditions: Burn scar.
Scar conditions and fibrosis of skin
L90.5

Registration Number: IRCT20210515051307N2

Lead Sponsor: Skin and Stem cellResearch Center of Tehran University

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 20

Inclusion Criteria

Patients with skin type 1-4
Patients with atrophic burn scars in more than one limb, from five years ago to the last 3 months

Exclusion Criteria

Age under 18 years.
Patients who have received laser treatment in the last three months
Patients with active colloidal scar or active skin lesion at the injection site
Patients with coagulation and platelet disorders
Patients with a history of taking anticoagulants
Patients with a history of underlying diseases such as diabetes and autoimmune connective tissue disease that affect the wound healing process
Patients with active viral infections
History of malignancy or receiving chemotherapy
Pregnancy and lactation

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The effectiveness of treatment. Timepoint: Before starting the trial, and two months after the last session of treatment. Method of measurement: Photography and biometry of the burn scars will be done. The scoring of the scars will be performed based on the Vancouver scoring system.;Patient satisfaction from treatment. Timepoint: In the second and third sessions of treatment with laser and two months after the last session. Method of measurement: Patient global assessment score.;Physician satisfaction from treatment. Timepoint: In the second and third sessions of treatment with laser and two months after the last session. Method of measurement: Physician global assessment score.

Secondary Outcome Measures