COMPARISON OF DEXMEDETOMIDINE AND REMIFENTANIL FOR POSTOPERATIVE PAIN IN TRANSPHENOIDAL Pituitary SURGERY

Completed

• Conditions: Postoperative Pain
• Interventions: Drug: Remifentanyl; Drug: Dexmedetomidine

• Registration Number: NCT05772832
• Lead Sponsor: Kocaeli University

Brief Summary

In patients with pituitary adenoma scheduled for endoscopic transsphenoidal pituitary surgery, it was aimed to compare the efficacy of postoperative pain relief of a selective α-2 agonist "Dexmedetomidine" and the rapid and short-acting opioid "Remifentanil" using the "Numerical Rating Scale" (NRS) administered alongside propofol in perioperative maintenance anesthesia. .

Detailed Description

Not available

Study Timeline

• Study Start: 2021-11-17
• Primary Completion: 2022-12-14
• Study First Submitted: 2023-02-18
• Study Completion: 2023-02-22
• Status Verified: 2023-03
• Study First Submitted QC: 2023-03-06
• Last Update Submitted: 2023-03-06
• Study First Posted: 2023-03-16
• Last Update Posted: 2023-03-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 84

Inclusion Criteria

• 18-65 years old
• ASA-1 and ASA-2 patients

Exclusion Criteria

• Patients in need of postoperative intensive care

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
GROUP USING REMIFENTANYL	Remifentanyl	THE GROUP USING PEROPERATIVE REMIFENTANYL AND PROPOFOL IN TRANSSPHENOIDAL Pituitary Surgery 0.01-0.2 μg /kg /min Remifentanyl and 3-12 mg/kg/h propofol
GROUP USING DEXMEDETOMIDINE	Dexmedetomidine	THE GROUP USING PEROPERATIVE DEXMEDETOMIDINE AND PROPOFOL IN TRANSSPHENOIDAL Pituitary Surgery 0.01-0.02 μg/kg/min (\~0.5 μg/kg/h) continuous infusion of dexmedetomidine 1 mcg/kg 10 minutes after a loading dose and 3-12 mg/kg/h propofol

Primary Outcome Measures

Name	Time	Method
postoperative pain scale	24 hours after surgery (T4)	Comparison of postoperative Numerical Rating Scale(NRS) values of both study arms(min 0, max 10; 10 is unbearable pain )

Secondary Outcome Measures

Name	Time	Method
Comparison of postoperative nausea-vomiting rate	24 hours after surgery (T4)	Comparison of postoperative nausea-vomiting rate
need for analgesics	Additional analgesic drug requirements at 24 hours after surgery (T4)	Comparison of whether there is a need for additional POSTOPERATIVE analgesic medication

Trial Locations

Locations (1)

University of Kocaeli; 🇹🇷 Kocaeli, Izmit, Turkey