Comparing the Efficacy of Perioperative Pain Control Between Intravenous Parecoxib and Oral Etoricoxib in ACL Reconstruction: A Randomized Controlled Trial
- Conditions
- Anterior cruciate ligament injury patients which underwent anterior cruciate ligament reconstruction surgery.Post-operative pain, ACL reconstruction
- Registration Number
- TCTR20230916002
- Lead Sponsor
- Faculty of Medicine, Prince of Songkla University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Enrolling by invitation
- Sex
- All
- Target Recruitment
- 160
The patients diagnosed as anterior cruciate ligament injury aged 18-50 years old who scheduled for arthroscopic ACLR.
1. Patient who schedules for bone-patellar tendon-bone autograft ACL reconstruction
2. Allergy to acetaminophen, aspirin, sulfonamide, NSAIDs or opioids
3. History of dyspepsia, peptic ulcer, or abnormal bleeding
4. History of ASCVD (History of diagnosis ACS, clinical likely ACS)
5. History of CKD
6. History of asthma or COPD because selective COX-inhibitor induce spasm
7. History of cerebrovascular disease
8. History of peripheral arterial disease
9. Patients who have Kratom or Marijuana used or substance abuse
10. Patients who anesthesiologist concerns the risk of general anesthesia (GA) is higher than spinal anesthesia; hence, they prefer to use spinal anesthesia rather than general anesthesia
11. Pre-operative abnormal EKG or laboratory result e.g., high Cr clearance, abnormal coagulogram
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain score Every 4 hours from post-op until 48 hours Questionnaire, VNRS
- Secondary Outcome Measures
Name Time Method Amount of rescue analgesic Within 24 hours post-op Medical record,Time to first dose of rescue analgesic Within 24 hours post-op Medical record,Side effect Within 48 hours post-op Questionnaire