Sodium Intake in Multiple Sclerosis

Completed

• Conditions: Multiple Sclerosis

• Registration Number: NCT01846234
• Lead Sponsor: Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia

Brief Summary

Recently, it has been shown that salt (ClNa, sodium chloride) can modulate the differentiation of human and mouse TH17 cells. Indeed, mice feed with high sodium diet were described to develop more aggressive course of EAE (Experimental Autoimmune Encephalitis).

However, the role of sodium intake in MS has not been investigated. In this study we investigate the effect of sodium intake in Multiple Sclerosis (MS) clinical and radiological activity.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-11
• Study First Submitted: 2013-05-01
• Study First Submitted QC: 2013-05-01
• Study First Posted: 2013-05-03
• Primary Completion: 2013-07
• Study Completion: 2013-07
• Status Verified: 2013-10
• Last Update Submitted: 2013-10-21
• Last Update Posted: 2013-10-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 132

Inclusion Criteria

• Subject is between 18 and 50 years old
• Subject has diagnosis of relapsing-remitting MS according to McDonald criteria (2010)

Exclusion Criteria

• Patient who had hyponatremia in the last 90 days

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Exacerbation rate	2 years	Number of disease relapses during follow up time according to salt consumption

Secondary Outcome Measures

Name	Time	Method
Radiological activity	One year	Number of new lesions in MRI

Trial Locations

Locations (1)

FLENI; 🇦🇷 Buenos Aires, Argentina