Chinese CKD-MBD Prevalence Survey (CRISS-MBD)
- Conditions
- Chronic Kidney Disease-Mineral and Bone DisorderChronic Kidney Diseases
- Registration Number
- NCT04714918
- Lead Sponsor
- Limeng Chen
- Brief Summary
This is a multi-center cross sectional epidemiological study. The purpose of this study is to investigate the prevalence of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) in Chinese population.
- Detailed Description
The prevalence of Chronic Kidney Disease (CKD) in Chinese population is over 10% and increasing rapidly. Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) is a constellation of conditions secondary to CKD, including 1) metabolic disorders of calcium, phosphorus and Parathyroid Hormone (PTH), 2) bone diseases and 3) calcifications in blood vessels and soft tissues. CKD-MBD could increase the risks of cardiovascular diseases and bone fracture and overall mortality. However, the data of prevalence of CKD-MBD in Chinese population with different CKD stages is lacking. This is a multi-center cross sectional epidemiological study. The purpose of this study is to investigate the prevalence of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) in Chinese population.This is a multi-center cross sectional epidemiological study. The purpose of this study is to investigate the prevalence of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) in Chinese population. A questionnaire was designed to collect the information of demographic data, medical history, laboratory test results and medications from the patients. Multistage stratified cluster sampling method will be used. Based on the sample size estimation, a total of 14-28 tertiary hospitals and 42-56 level II hospitals distributed in seven different geographic regions across China will be included. At least 9863 subjects will be enrolled. The primary outcome is the prevalence of CKD-MBD, including the prevalence of hypocalcemia, hyperphosphatemia and secondary hyperparathyroidism.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 10254
-
Kidney damage for β₯ 3 months, and one of the following criteria:
- Glomerular filtration rate (GFR) <60 mL/min/1.73m2 for 3 months or more, irrespective of cause.
- proteinuria (>30 mg of urinary albumin excretion per gram of urinary creatinine, > 50 mg of urinary protein excretion per gram of urinary creatinine, >1+ for proteinuria in dipstick, > 0.3g of 24 hour urine protein)
- structural renal abnormalities
-
hospitalized patients not on dialysis or dialysis patients followed regularly in Hemodialysis centers or Peritoneal Dialysis centers
- no available test results within 3 months prior to this study
- no available information of medication or past medical history
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The prevalence of hyperphosphatemia At the end of the enrollment. The prevalence of hyperphosphatemia (serum phosphate \> 1.45mmol/L) in the whole study population and in participants with different CKD stages.
- Secondary Outcome Measures
Name Time Method The prevalence of hypocalcemia At the end of the enrollment. The prevalence of hypocalcemia (serum calcium \< 2.13mmol/L) in the whole study population and in participants with different CKD stages.
The prevalence of secondary hyperparathyroidism At the end of the enrollment. The prevalence of secondary hyperparathyroidism (iPTH \> 300pg/ml) in the whole study population and in participants with different CKD stages.
The prevalence of bone fracture At the end of the enrollment. The prevalence of bone fracture in the whole study population and in participants with different CKD stages.
The prevalence of hypercalcemia At the end of the enrollment. The prevalence of hypercalcemia (serum calcium \> 2.70mmol/L) in the whole study population and in participants with different CKD stages.
The prevalence of vascular calcification At the end of the enrollment. The prevalence of vascular calcification identified by CT scan or ultrasound in the whole study population and in participants with different CKD stages.
Trial Locations
- Locations (40)
The First Hospital of Fangshan District, Beijing
π¨π³Beijing, Beijing, China
Third People's Hospital of Yiyang
π¨π³Yiyang, Hunan, China
The Fifth People's Hospital of Ningxia Hui Autonomous Region
π¨π³Shizuishan, Ningxia, China
People's Hospital of Wuzhong
π¨π³Wuzhong, Ningxia, China
People's Hospital of Tongxin County
π¨π³Wuzhong, Ningxia, China
People's Hospital of Yanchi County
π¨π³Wuzhong, Ningxia, China
People's Hospital of Yuanzhou District
π¨π³Wuzhong, Ningxia, China
Ningxia Chinese Medicine Research Center
π¨π³Yinchuan, Ningxia, China
People's Hospital of Ningxia Hui Autonomous Region
π¨π³Yinchuan, Ningxia, China
People's Hospital of Xinjiang Uygur Autonomous Region
π¨π³ΓrΓΌmqi, Xinjiang, China
The Second Affiliated Hospital Zhejiang University School of Medicine
π¨π³Hangzhou, Zhejiang, China
Beijing Tiantan Hospital, Capital Medical University
π¨π³Beijing, Beijing, China
Peking Union Medical College Hospital
π¨π³Beijing, Beijing, China
Beijing Lu-He Hospital, Capital Medical University
π¨π³Beijing, Beijing, China
The First Affiliated Hospital, Chongqing Medical University
π¨π³Chongqing, Chongqing, China
Beijing Daxing District People's Hospital
π¨π³Beijing, Beijing, China
Chongqing Hospital of Traditional Chinese Medicine
π¨π³Chongqing, Chongqing, China
The Ninth People's Hospital of Chongqing
π¨π³Chongqing, Chongqing, China
The Third Affiliated Hospital of Chongqing Medical University
π¨π³Chongqing, Chongqing, China
People's Hospital of Liangping District, Chongqing
π¨π³Chongqing, Chongqing, China
The People's Hospital of Fengdu County
π¨π³Chongqing, Chongqing, China
The People's Hospital of Nanchuan District, Chongqing
π¨π³Chongqing, Chongqing, China
Fujian Provincial Hospital
π¨π³Fuzhou, Fujian, China
Zhongshan Hospital Affiliated to Xiamen University
π¨π³Xiamen, Fujian, China
Shunde Hospital of Southern Medical University, The first People's Hospital of Shunde
π¨π³Foshan, Guangdong, China
The Seventh Affiliated Hospital, Sun Yat-sen University
π¨π³Shenzhen, Guangdong, China
Zhangzhou People's Hospital
π¨π³Zhangzhou, Fujian, China
Panyu Central Hospital
π¨π³Guangzhou, Guangdong, China
The People's Hospital of Longhua, The Affiliated Hospital of Southern Medical University
π¨π³Shenzhen, Guangdong, China
The First Affiliated Hospital of Guangxi Medical University
π¨π³Nanning, Guangxi, China
Xiangya Hospital of Central South University
π¨π³Changsha, Hunan, China
Anshan Central Hospital, Lishan District
π¨π³Anshan, Liaoning, China
Benxi Steel General Hospital of Liaoning Health Industry Group
π¨π³Benxi, Liaoning, China
Dalian University Affiliated Xinhua Hospital
π¨π³Dalian, Liaoning, China
The First Hospital of China Medical University
π¨π³Shenyang, Liaoning, China
Traditional Chinese Hospital of Guyuan
π¨π³Guyuan, Ningxia, China
People's Hospital of Longde County
π¨π³Guyuan, Ningxia, China
The First People's Hospital of Yinchuan
π¨π³Yinchuan, Ningxia, China
Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
π¨π³Guangzhou, Guangdong, China
Beijing Tongren Hospital, Capital Medical University
π¨π³Beijing, Beijing, China