Critical Care Excellence in Sepsis and Trauma

The impetus for CREST derives from the observation that rural patients are unlikely to acquire on-site access to appropriate specialist care for high stakes, high acuity, crisis-mode conditions such as sepsis and trauma. Novel, collaborative approaches are necessary to provide rural patients with access to appropriate specialist care for sepsis and trauma. CREST is an innovative, technologically levering mechanism that provides the opportunity to lessen the inferior outcomes and "rural penalty" paid by patients in rural communities.

Rural patients are less likely to have onsite access to specialist care for sepsis and trauma for several reasons:

• Personnel: there is a nation-wide shortage of appropriate specialty providers including intensivists, trauma surgeons, and other critical care staff 1. Small, rural communities lack the economies of scale to support resource intense services and if a community has these specialties, there is often not around the clock coverage necessary for best quality care for these conditions 1.
• Physical and material resources: Sepsis and trauma patients require immediate availability of resources such as multidisciplinary ICU staff, large blood banks, operating rooms, and advanced radiological facilities.
• Availability of resources such as multidisciplinary ICU staff, large blood banks, operating rooms, and advanced radiological facilities.
• Location and distance: Patients in rural communities have inferior outcomes in sepsis and trauma 2, 3. This is likely multifactorial and includes delays in entry to the Emergency Medical System network, longer travel times to definitive care facilities and delays in definitive care delivery. Inter-hospital transfer may be limited both by severity of patient illness, acute care and ICU bed shortages in tertiary care centers. Additionally, the scarcity of tertiary care hospital beds increases the importance of initiating transfer for patients who will maximally benefit from tertiary care referral 4, 5.

The impact to rural patients with sepsis and trauma, due to lack of access to appropriate specialist care, is substantial. Sepsis is one of the most common serious critical illnesses. It kills 28-50% of patients diagnosed 6, 7 and is the 10th leading cause of death in the US 8. Furthermore, the incidence is increasing in conjunction with the aging of the US population 9. The impact of rurality on sepsis has received modest investigation, but rural patients likely have worse outcomes.3 In SC, patients referred from Emergency Departments (ED's) in smaller, typically rural hospitals have a 22% increase risk of death as compared to those referred from ED's in larger, urban hospitals (CREST preliminary analysis) suggesting the benefits of specialist directed care available to patients at larger facilities. Equally concerning is an apparent race-associated disparity in which African American patients presenting to rural ED's in SC are twice as likely to be discharged from the ED with a diagnosis of sepsis as compared to white patients. Although the rates for discharge from an ED with a diagnosis of sepsis are low at 3.95% for whites and 8.71% for African Americans (CREST preliminary analysis), it is concerning that any patient is discharged from an ED with this diagnosis and the disparate rates may reflect the well-described phenomenon of unequal treatment 10. Critically ill patients with any diagnosis benefit from intensivist-directed care including a 30-40% reduction in mortality.11 Unfortunately, over half of US hospitals have no intensivist coverage at all and rural hospitals are disproportionately affected by this problem 12.

Likewise, trauma is the leading cause of death among Americans up to age 45 and the fourth leading cause of death overall for all ages 8. Deaths from injury occur in a tri-phasic distribution: 50% of deaths from injury occur at the scene, 30% occur in the first 1-2 hours and 20% occur during hospitalization between 1-2 weeks after admission. Trauma care at designated trauma centers improves survival 13. Yet, rural hospitals are rarely trauma centers and in SC patients injured in rural communities have inferior outcomes and higher costs 14. Significant disparities can be identified among SC's elderly and minority populations. 14 An important barrier to facilitating quality care for SC trauma patients relates to triage efficiency between rural hospitals and a trauma center. Outcomes for seriously injured rural patients are negatively affected when patients are taken to non-trauma EDs and then transferred to a trauma center 13 . Conversely, transfer of patients with low risk of death and disability to trauma centers represents over-triage, and creates additional stressors at already busy trauma centers accruing financial burden on the health care system.