Prospective International Study of Coronary Subtraction Using 320 Detector Row CT (CorSub)
- Conditions
- Coronary Artery Disease
- Registration Number
- NCT02303067
- Brief Summary
Background:
- This study is designed for people who need a standard, non-research invasive coronary angiogram to find out if they have heart disease. Researchers want to take a computed tomography (CT) scan of people s hearts before their procedure to see if this less invasive test can also diagnose coronary artery disease.
Objectives:
- To learn if a new way to view CT pictures is able to accurately diagnose coronary artery disease.
Eligibility:
- People age 55 and older who need a coronary angiogram.
Design:
* Participants will be screened with their medical records.
* Participants may give a blood sample.
* Participants may have a CT scan of the heart with and without contrast. The CT scan will not interfere with their medical care.
* Participants blood pressure and heart rhythm will be monitored before, during, and after the CT scan. They may have an electrocardiogram.
* Before the scan, participants will have an intravenous catheter put into their arm. It will be used to inject contrast.
* Participants may take a beta blocker to slow their heart rate.
* Participants may take nitroglycerin under their tongue. It will enlarge their heart blood vessels and improve picture quality. It may cause a flushing sensation or headache.
* Participants will lie on their back on a padded table. The table slides into a large, donut-shaped machine. An x-ray tube will move around their body, taking pictures. They will be asked to hold their breath for 5 seconds at a time.
* Participants will be called 30 days after their angiogram. They will answer questions about their health, hospital visits, or medical treatments.
- Detailed Description
Coronary calcium can impair the accurate evaluation of the coronary arteries with coronary computed tomography angiography (CCTA). A novel approach to potentially overcome this limitation is coronary calcium subtraction, where areas of calcification identified on a non-contrast scan are removed from the contrast enhanced images.
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Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 13
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Coronary substraction CCTA improves the diagnostic accuracy. 3 months
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
Rigshospitalet
🇩🇰Copenhagen, Denmark
National Institutes of Health Clinical Center, 9000 Rockville Pike
🇺🇸Bethesda, Maryland, United States