Effect of β-alanine Supplementation and Training on Ergogenic Parameters and Plasma Metabolites in Untrained Young Adults: a Randomized, Placebo-controlled, Double-blind Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 46
- 试验地点
- 1
- 主要终点
- Change in maximal muscle strength
研究概览
简要总结
This study enrolled untrained young adults to evaluate the effects of β-alanine supplementation combined with a structured exercise training program. Participants were randomly assigned to receive either β-alanine or a placebo while completing a six-week training regimen. Before and after the intervention, physical performance tests and blood samples were collected to assess changes in performance measures and biochemical markers in the blood. The purpose of the study was to determine how β-alanine supplementation influences exercise performance and related physiological outcomes in individuals who had not previously engaged in regular training.
详细描述
This randomized, double-blind, placebo-controlled study was conducted to evaluate the effects of β-alanine supplementation combined with a structured exercise training program in untrained young adults. Participants were randomly assigned to receive either β-alanine supplementation or a matching placebo while completing a six-week supervised training intervention. Both participants and investigators responsible for training supervision and outcome assessments were blinded to group allocation.
The primary outcome measures focused on changes in physical performance capacity. Maximal muscle strength was assessed using standardized dynamometric measurements, and aerobic capacity was evaluated using a validated shuttle run test performed before and after the intervention.
Secondary outcome measures included changes in anthropometric parameters, pulmonary function, and exercise-related metabolic responses. Blood lactate concentrations were measured during standardized exercise testing to characterize metabolic responses to training and supplementation. In addition, fasting venous blood samples were collected before and after the intervention to determine plasma concentrations of β-alanine, histidine, and carnosine as biochemical outcome measures related to supplementation and training adaptation.
All outcome measures were collected at baseline and following completion of the six-week intervention period. Adverse events were monitored throughout the study duration through participant self-report and investigator observation. All study procedures were performed in accordance with ethical approval and institutional guidelines.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy young adults aged 18-30 years.
- •Untrained individuals without participation in structured resistance or endurance training during the previous 6 months.
- •Not physically inactive, but not engaged in regular structured exercise training.
- •Ability to participate in a six-week supervised multicomponent exercise training program.
- •Willingness to comply with study procedures, training sessions, and supplementation protocol.
- •Provision of written informed consent.
排除标准
- •Known cardiovascular, metabolic, neuromuscular, or musculoskeletal disease.
- •Acute injury at the time of enrollment.
- •Regular use of medications or dietary supplements affecting muscle metabolism or exercise performance.
- •Participation in structured resistance or endurance training during the previous 6 months.
- •Failure to comply with the study protocol or training requirements.
研究组 & 干预措施
Placebo
Participants received a visually identical placebo following the same dosing schedule as the supplementation group, in combination with a supervised six-week exercise training program.
干预措施: Placebo (Dietary Supplement)
β-Alanine Supplementation
Participants received β-alanine supplementation at a dose of 50 mg/kg/day, divided into multiple daily doses, in combination with a supervised six-week exercise training program.
干预措施: β-Alanine (Dietary Supplement)
结局指标
主要结局
Change in maximal muscle strength
时间窗: Baseline and 6 weeks
Maximal muscle strength was assessed by dynamometric measurements of maximal voluntary isometric contraction.
Change in aerobic capacity
时间窗: Baseline and 6 weeks
Aerobic capacity was estimated by VO₂max derived from the 20-m multistage fitness test (shuttle run).
次要结局
- Body mass index (BMI)(Baseline and 6 weeks)
- Body fat percentage(Baseline and 6 weeks)
- Forced vital capacity (FVC)(Baseline and 6 weeks)
- Acute blood lactate response to dynamometric exercise(Baseline and 6 weeks)
- Plasma β-alanine concentration(Baseline and 6 weeks)
- Plasma histidine concentration(Baseline and 6 weeks)
- Plasma carnosine concentration(Baseline and 6 weeks)
研究者
David Csala
Principal Investigator
University of Pecs