ACTRN12624001150538尚未招募Unknown
Creatine and Exercise as a Novel Treatment Strategy for Depression in Adults Aged 18-39 Years
Swinburne University0 个研究点目标入组 36 人开始时间: 2024年9月23日最近更新:
适应症
试验速览
- 阶段
- Unknown
- 状态
- 尚未招募
- 发起方
- 入组人数
- 36
- 主要终点
- Depression[Participant responses to the following questionnaire: Patient Health Questionnaire-9 (PHQ-9) Pre-intervention (0 weeks); Post-intervention (6 weeks post intervention commencement)];Depression[Participant responses to the following questionnaires: Montgomery-Asberg Depression Rating Scale (MADRS) and Depression Anxiety and Stress Scale 21 (DASS-21). Pre-intervention (0 weeks); Post-intervention (6 weeks post intervention commencement)]
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 39 Years（—）
- 性别
- All
入选标准
- •Aged 18-39 years.- Mild-moderate depression severity (scoring between 5-19 on the Patient Health Questionnaire-9, PHQ-9)- Body mass index (BMI) is between 18.5-29.9 kg/m².- Sedentary (less than 150 min/week exercise/ physical activity)- Not involved in a structured exercise program involving more than 2 exercise sessions per week in the last 6 months
排除标准
- •Hazardous alcohol or tobacco use using the AUDIT Alcohol Screening Tool- No current or previous use of creatine supplements - Physically active (greater than 150 min/week exercise/ physical activity)- Serious somatic disorder based on a previous diagnosis from a Medical Doctor- Psychiatric treatment- Moderately severe and severe depression (PHQ-9>14 or >20 respectively).- Body mass index (BMI) above 29.9 kg/m²- Asthma- Any current or history of respiratory or cardiac conditions- Diabetes- Pre-existing renal disease or proteinuria on baseline urinalysis testing- History of creatinine hypersensitivity - Concomitant treatment with antiepileptic or antipsychotic medications- Neurological or psychiatric disorder- Clinically significant suicidal or homicidal risk
结局指标
主要结局
Depression[Participant responses to the following questionnaire: Patient Health Questionnaire-9 (PHQ-9) Pre-intervention (0 weeks); Post-intervention (6 weeks post intervention commencement)];Depression[Participant responses to the following questionnaires: Montgomery-Asberg Depression Rating Scale (MADRS) and Depression Anxiety and Stress Scale 21 (DASS-21). Pre-intervention (0 weeks); Post-intervention (6 weeks post intervention commencement)]
次要结局
- Muscle Strength[Composite measures of 1-Repetition Maximum Strength for the Bench Press (Upper Body including Pec Major, Shoulders and arms) and Leg Press (Lower Body including hip flexors, quads, gluteals and hamstrings) Pre-intervention (0 weeks); Post-intervention (6 weeks post intervention commencement)];Circulating levels of Brain Derived Neutrophic Factor (BDNF)[ELISA Pre-intervention (0 weeks); Post-intervention (6 weeks post intervention commencement)]
研究者
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