Creatine and Exercise as a Novel Treatment Strategy for Depression in Adults Aged 18-39 Years

Not Applicable

Not yet recruiting

• Conditions: Depression; Mental Health - Depression; Physical Medicine / Rehabilitation - Other physical medicine / rehabilitation

• Registration Number: ACTRN12624001150538
• Lead Sponsor: Swinburne University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2024-09-23
• Last Update Posted: 30 September 2024

Recruitment & Eligibility

• Status: Not yet recruiting
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

Aged 18-39 years.- Mild-moderate depression severity (scoring between 5-19 on the Patient Health Questionnaire-9, PHQ-9)- Body mass index (BMI) is between 18.5-29.9 kg/m².- Sedentary (less than 150 min/week exercise/ physical activity)- Not involved in a structured exercise program involving more than 2 exercise sessions per week in the last 6 months

Exclusion Criteria

• Hazardous alcohol or tobacco use using the AUDIT Alcohol Screening Tool- No current or previous use of creatine supplements - Physically active (greater than 150 min/week exercise/ physical activity)- Serious somatic disorder based on a previous diagnosis from a Medical Doctor- Psychiatric treatment- Moderately severe and severe depression (PHQ-9>14 or >20 respectively).- Body mass index (BMI) above 29.9 kg/m²- Asthma- Any current or history of respiratory or cardiac conditions- Diabetes- Pre-existing renal disease or proteinuria on baseline urinalysis testing- History of creatinine hypersensitivity - Concomitant treatment with antiepileptic or antipsychotic medications- Neurological or psychiatric disorder- Clinically significant suicidal or homicidal risk

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Depression[Participant responses to the following questionnaire: Patient Health Questionnaire-9 (PHQ-9) Pre-intervention (0 weeks); Post-intervention (6 weeks post intervention commencement)];Depression[Participant responses to the following questionnaires: Montgomery-Asberg Depression Rating Scale (MADRS) and Depression Anxiety and Stress Scale 21 (DASS-21). Pre-intervention (0 weeks); Post-intervention (6 weeks post intervention commencement)]

Secondary Outcome Measures

Name	Time	Method
Muscle Strength[Composite measures of 1-Repetition Maximum Strength for the Bench Press (Upper Body including Pec Major, Shoulders and arms) and Leg Press (Lower Body including hip flexors, quads, gluteals and hamstrings) Pre-intervention (0 weeks); Post-intervention (6 weeks post intervention commencement)];Circulating levels of Brain Derived Neutrophic Factor (BDNF)[ELISA Pre-intervention (0 weeks); Post-intervention (6 weeks post intervention commencement)]