The Prognostic Impact of Right Ventricular Systolic Dysfunction on the Survival of Patients With Sepsis and Septic Shock
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Sepsis and Septic Shock
- Sponsor
- Burapha University
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- 28 days in-hospital mortality
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
This study sought to evaluate the association of right ventricular systolic dysfunction and 28-day in-hospital mortality in patients with sepsis and septic shock. Prospective cohort study of adult patients admitted at Burapha university hospital from October 1, 2022 through June 30, 2023 for sepsis and septic shock, who had an echocardiogram within 72 hours after admission for evaluating right ventricular systolic function. Right ventricular systolic dysfunction was defned by the American Society of Echocardiography criteria. Outcomes included 28-day in-hospital mortality, maximal blood lactate, length of intensive care unit(ICU) stay and duration of mechanical ventilation.
Investigators
Sukrisd Koowattanatianchai
Assistant Professor Dr.
Burapha University
Eligibility Criteria
Inclusion Criteria
- •aged 18 years or older
- •diagnosed with sepsis or septic shock according to Sepsis-3 criteria
- •received an echocardiogram within 72 hours after admission
Exclusion Criteria
- •prior diagnosis of pulmonary hypertension,
- •cor-pulmonale,
- •significant valvular heart disease,
- •acute coronary syndrome,
- •aortic dissection,
- •heart failure
- •inability to follow up within 28 days
Outcomes
Primary Outcomes
28 days in-hospital mortality
Time Frame: October 1, 2022 and June 30, 2023
28 days in hospital mortality in patients with sepsis or septic shock
Secondary Outcomes
- Duration of mechanical ventilation(October 1, 2022 and June 30, 2023)
- The prevalence of right ventricular systolic dysfunction(October 1, 2022 and June 30, 2023)
- Blood lactate levels(October 1, 2022 and June 30, 2023)
- Lenght of ICU stay(October 1, 2022 and June 30, 2023)