The Prognostic Impact of Right Ventricular Systolic Dysfunction on the Survival of Patients With Sepsis and Septic Shock

Completed

• Conditions: Sepsis and Septic Shock

• Registration Number: NCT06193109
• Lead Sponsor: Burapha University

Brief Summary

This study sought to evaluate the association of right ventricular systolic dysfunction and 28-day in-hospital mortality in patients with sepsis and septic shock. Prospective cohort study of adult patients admitted at Burapha university hospital from October 1, 2022 through June 30, 2023 for sepsis and septic shock, who had an echocardiogram within 72 hours after admission for evaluating right ventricular systolic function. Right ventricular systolic dysfunction was defned by the American Society of Echocardiography criteria. Outcomes included 28-day in-hospital mortality, maximal blood lactate, length of intensive care unit(ICU) stay and duration of mechanical ventilation.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-10-01
• Primary Completion: 2023-06-30
• Study Completion: 2023-07-30
• Status Verified: 2023-12
• Study First Submitted: 2023-12-12
• Study First Submitted QC: 2023-12-21
• Last Update Submitted: 2023-12-21
• Study First Posted: 2024-01-05
• Last Update Posted: 2024-01-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• aged 18 years or older
• diagnosed with sepsis or septic shock according to Sepsis-3 criteria
• received an echocardiogram within 72 hours after admission

Exclusion Criteria

• prior diagnosis of pulmonary hypertension,
• cor-pulmonale,
• significant valvular heart disease,
• acute coronary syndrome,
• aortic dissection,
• heart failure
• inability to follow up within 28 days

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
28 days in-hospital mortality	October 1, 2022 and June 30, 2023	28 days in hospital mortality in patients with sepsis or septic shock

Secondary Outcome Measures

Name	Time	Method
Duration of mechanical ventilation	October 1, 2022 and June 30, 2023	Duration of mechanical ventilation in patients with sepsis and septic shock
The prevalence of right ventricular systolic dysfunction	October 1, 2022 and June 30, 2023	The prevalence of right ventricular systolic dysfunction in patients with sepsis and septic shock
Blood lactate levels	October 1, 2022 and June 30, 2023	Blood lactate levels in patients with sepsis and septic shock
Lenght of ICU stay	October 1, 2022 and June 30, 2023	Lenght of ICU stay in patients with sepsis and septic shock

Trial Locations

Locations (1)

Burapha University Hospital; 🇹🇭 Muang Chonburi, Chonburi, Thailand