Placebo-controlled psychometric investigation of percutaneous auricular vagus nerve stimulation (pVNS) in healthy volunteers using PrimeStim
Not Applicable
- Conditions
- Healthy volunteers
- Registration Number
- DRKS00022427
- Lead Sponsor
- Institute for Biomedical Engineering University of Zurich and ETH Zurich Translational Neuromodeling Unit (TNU)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
none
Exclusion Criteria
1. medical conditions related to the metabolic, respiratory, caridiac, and capillary
2. serious past or present brain disease, brain injury or brain surgery
3. acute or chronic psychological or physical diseases
4. current medication (except hormonal contraceptives)
5. implanted active medical devices
6. permanent ear piercings
7. women: pregnancy and breast feeding
8. past or present nicotine and/or durg abuse
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcomes entail (i) the determination of individual detection amplitudes (ii) and the determination of optimal stimulation amplitudes based on changes in physiological parameters.
- Secondary Outcome Measures
Name Time Method The secondary outcomes entail (i) the evaluation of respiration and subjective reports regarding bodily sensations, (ii) a possible relationship between stimulation amplitudes and learning in the exteroceptive domain.
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie parasympathetic activation via percutaneous auricular vagus nerve stimulation (pVNS) in healthy volunteers?
How does pVNS using PrimeStim compare to transcutaneous vagus nerve stimulation (tVNS) in modulating autonomic nervous system biomarkers?
Which inflammatory or neurochemical biomarkers correlate with placebo-controlled pVNS efficacy in clinical trials?
What adverse events are reported in auricular branch vagus nerve stimulation studies, and how are they managed in translational research?
Are there synergistic effects of combining pVNS with pharmacological agents like SSRIs or anti-inflammatory drugs in neuropsychiatric conditions?