Clinical study to compare effects radiation alone and radiation with temozolomide in patients with brain metastasis from lung and breast cancer
Phase 3
- Conditions
- Health Condition 1: null- Cases of carcinoma lung and breast with newly diagnosed brain metastasis
- Registration Number
- CTRI/2013/06/003746
- Lead Sponsor
- Regional cancer centreThiruvananthapuram
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 96
Inclusion Criteria
1.patients registered at Regional cancer centre, Thiruvananthapuram
2. Age 18-70Years
3.KPS >70
4.Histologically proven primary cancer from lung&breast
5.Documented brain metastasis (contrast enhanced CT or Gd enhanced MRI)
6.Not suitable for surgery or stereotactic radiosurgery
7. Life expectancy >3months
8.Normal biochemical and hematologic parameters
9.informed consent
10.As and when indicated chemotherapy for systemic progression will be permitted according to clinical indication on completion of radiotherapy
Exclusion Criteria
EXCLUSION CRITERIA
1.prior radiothrapy for brain metastasis
2.severe intercurrent medical illness
-symptomatic heart disease
-uncontrolled diabetes mellitus
3. pregnancy/lactating women
4.Known psychiatric illness
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method