Diphenhydramine in Catheter Related Bladder Discomfort
- Conditions
- Catheter Complications
- Interventions
- Registration Number
- NCT06345261
- Lead Sponsor
- Cairo University
- Brief Summary
Diphenhydramine has H1-antihistamine action, it also possesses anti-muscarinic properties. Thus, diphenhydramine might be able to reduce the problem of catheter related bladder discomfort by inhibiting smooth muscle spasm of the urinary bladder via its anti-muscarinic action .
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ENROLLING_BY_INVITATION
- Sex
- Male
- Target Recruitment
- 104
male patients aged more than18-80 years ASA I and II , upper ureteric stone removal under general anesthesia r
overactive bladder cognitive impairment a neuropsychological disorder, bladder outflow obstruction urinary tract infection, , neurogenic bladder, operative time > 6 h
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Diphenhydramine group DiphenhydrAMINE 50 Mg/mL Injectable Solution - control group Saline -
- Primary Outcome Measures
Name Time Method incidence of catheter related bladder discomfort postoperative UP TO 6 HOURE * none, did not complain of any CRBD even upon asking.
* mild, revealed only on questioning.
* moderate, reported without questioning but not accompanied by any behavioral response.
* severe, stated on their own and followed by behavioral responses such as a strong verbal response, flailing limbs, and even attempting to pull out the urinary catheter
- Secondary Outcome Measures
Name Time Method visual analog scale (VAS) up to 6 hours 0 (no pain) to 10 (the worst imaginable pain)
Trial Locations
- Locations (1)
Cairo university
🇪🇬Cairo, Egypt