NCT00214630已完成3 期
A 12-week Randomized, Open-label 3-arm, Parallel Group, Multicenter Phase IIIb Study Comparing Efficacy and Safety of Rosuvastatin 20mg and 40mg With That of Atorvastatin 80 mg in Subjects With Acute Coronary Syndromes
适应症
相关药物
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- AstraZeneca
- 入组人数
- 825
- 试验地点
- 56
- 主要终点
- Reduction of LDL-C following 12 weeks of treatment
研究概览
简要总结
Comparison of rosuvastatin and atorvastatin in subjects with acute coronary syndromes
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Non-ST segment elevation ACS and ST segment elevation ACS who receive optimal reperfusion therapy
排除标准
- •Previous Q-wave infarct within the last 4 weeks
- •CK elevation not caused by myocardial injury
- •uncontrolled hypertension at time of randomization
结局指标
主要结局
Reduction of LDL-C following 12 weeks of treatment
次要结局
- % change from baseline in LDL-C following 2 & 6 weeks of treatment; % change from baseline in TC, HDL-C, triglycerides, non-HDL-C, apolipoprotein A-1, apolipoprotein B, LDL-C/HDL-C, TC/HDL-C, non-HDL-C/HDL-C, ApoB/Apo A-1 @ weeks 6 & 12
研究者
研究点 (56)
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