NCT02912910撤回不适用
Changes in Central Arterial Pressure When Comparing Nifedipine and Labetalol for Routine Hypertension Control in Pregnancy
适应症
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 主要终点
- central blood pressure changes
研究概览
简要总结
To study central blood pressure changes caused by commonly used high blood pressure medications in pregnancy.
详细描述
Central blood pressures in addition to pulse wave velocity will be attained prior to medication, and then every 30 minutes for 4 hours (total of 9 readings). Sphygmomanometer readings will be completed at the same time (total readings 9). These readings are all related to the study.
Nursing will have the opportunity to to record the routine sphygmomanometer readings for their routine vitals if they chose to do so.
Their participation will be complete after the 4 hour assessment is complete.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 14 Years 至 50 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Singleton pregnancy
- •Women with hypertensive disease in pregnancy who are currently being treated with nifedipine xl or labetalol
排除标准
- •Multiple pregnancy
- •Currently on multiple anti-hypertension medications
- •Narcotic use
- •Irregular heart rhythms or arrhythmias
- •Peripheral arterial disease, leg artery disease
- •Reynaud's phenomena
- •Intense cold/hypothermia
- •If there is a wound at location of where central arterial cuff would be placed or tonometer for carotid assessment
- •Known sensitivity to labetalol or nifedipine
- •Severe tachycardia (>120)
- •Greater than 1st degree heart block
- •Severe asthma
- •Congestive heart failure or heart disease
- •Inability to adequately monitor BP
- •Currently receiving magnesium sulfate
结局指标
主要结局
central blood pressure changes
时间窗: every 30 min for 4 hours
次要结局
未报告次要终点
研究者
Jennifer Goldkamp, MD
MD
St. Louis University
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