Evaluation of the Systemic Microcirculation in the Course of Cardiopulmonary Bypass Used in the Surgery for Repair of Congenital Heart Defects in Infants and Children
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Congenital Heart Disease
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Microcirculatory alterations during cardiopulmonary bypass
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
General objective of the research project: To evaluate the alterations of systemic microvascular reactivity during cardiopulmonary bypass (CPB), in children submitted to cardiac surgery for repair of congenital heart defects.
Detailed Description
• Specific objectives: * To test the usefulness of skin laser Doppler flowmetry monitoring (LDPM) in the non-invasive evaluation of endothelium-dependent microvascular reactivity during CPB in children. * To investigate whether skin LDPM could be proposed as a clinical monitoring of tissue perfusion during CPB in pediatric cardiac surgery. * To investigate the effects of different anesthetic agents on microvascular reactivity during CPB. * To investigate the effects of cardiovascular and vasoactive drugs used during CPB on microvascular reactivity. * To evaluate the correlation of microcirculatory alterations observed during CPB with classical markers of tissue perfusion and oxygenation, including plasma lactate levels. * To evaluate the correlation of microcirculatory alterations observed during CPB with markers of systemic inflammation, including pro- and anti-inflammatory cytokines. * To evaluate the correlation of microcirculatory alterations observed during CPB with the plasma bioavailability of nitric oxide.
Investigators
Eduardo Tibirica, MD, PhD
Senior Researcher
National Institute of Cardiology, Laranjeiras, Brazil
Eligibility Criteria
Inclusion Criteria
- •infants and children with congenital heart defects scheduled to corrective cardiac surgery
Exclusion Criteria
- •age inferior to 3 months and superior to 6 years
Outcomes
Primary Outcomes
Microcirculatory alterations during cardiopulmonary bypass
Time Frame: december 2019
Evaluation of the alterations of microcirculatory parameters and tissue perfusion during cardiopulmonary bypass in children submitted to cardiac corrective surgery for congenital heart defects