NCT03144258已完成不适用
Evaluation of the Systemic Microcirculation in the Course of Cardiopulmonary Bypass Used in the Surgery for Repair of Congenital Heart Defects in Infants and Children
National Institute of Cardiology, Laranjeiras, Brazil1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2018年2月20日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Microcirculatory alterations during cardiopulmonary bypass
研究概览
简要总结
General objective of the research project: To evaluate the alterations of systemic microvascular reactivity during cardiopulmonary bypass (CPB), in children submitted to cardiac surgery for repair of congenital heart defects.
详细描述
• Specific objectives:
- To test the usefulness of skin laser Doppler flowmetry monitoring (LDPM) in the non-invasive evaluation of endothelium-dependent microvascular reactivity during CPB in children.
- To investigate whether skin LDPM could be proposed as a clinical monitoring of tissue perfusion during CPB in pediatric cardiac surgery.
- To investigate the effects of different anesthetic agents on microvascular reactivity during CPB.
- To investigate the effects of cardiovascular and vasoactive drugs used during CPB on microvascular reactivity.
- To evaluate the correlation of microcirculatory alterations observed during CPB with classical markers of tissue perfusion and oxygenation, including plasma lactate levels.
- To evaluate the correlation of microcirculatory alterations observed during CPB with markers of systemic inflammation, including pro- and anti-inflammatory cytokines.
- To evaluate the correlation of microcirculatory alterations observed during CPB with the plasma bioavailability of nitric oxide.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 3 Months 至 6 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •infants and children with congenital heart defects scheduled to corrective cardiac surgery
排除标准
- •age inferior to 3 months and superior to 6 years
结局指标
主要结局
Microcirculatory alterations during cardiopulmonary bypass
时间窗: december 2019
Evaluation of the alterations of microcirculatory parameters and tissue perfusion during cardiopulmonary bypass in children submitted to cardiac corrective surgery for congenital heart defects
次要结局
未报告次要终点
研究者
Eduardo Tibirica, MD, PhD
Senior Researcher
National Institute of Cardiology, Laranjeiras, Brazil
研究点 (1)
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