The Effects of tDCS on Pain and Metabolite Changes in Patient with Spinal Cord Injury and Neuropathic Pain

Khon Kaen University0 个研究点目标入组 10 人开始时间: 2017年8月22日最近更新: 2024年8月19日

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•(1) right handed traumatic spinal cord injury due to an accident, a gunshot, or disease; (2) bilateral pain that was had the same intensity on both sides of the body with an average pain intensity rating before tDCS treatment of 4 or greater, as measured by a 0-10 numerical rating scale (0 = â€œNo painâ€ to 10 = â€œWorst pain that you could imagineâ€); (3) presenting with a pain problem that was refractory to medications, including tricyclic antidepressants, antiepileptic drugs, and/or opioids (i.e., pain that does not respond to at least two of these drugs supplied in adequate doses for 6 months); (4) no evidence of progressive neurological disease or other secondary conditions that could impact pain; and (5) not having used an alternative treatment for pain (herbal remedies and other alternative therapies) in the previous month.

•(1) a diagnosis of syringomyelia; (2) current or history of drug abuse or addiction; (3) current psychiatric disorder such as schizophrenia (per medical record), depression (as indicated by a score of 16 or greater on the Beck Depression Inventory(BDI); Wongchai, 2003) or severe anxiety (as indicated by a score of 39 or lower â€ lower scores indicate greater anxiety â€ on the Anxiety scale of the Symptom Checklist-90 [SCL-90; Department of Mental Health, 2011a]); (4) significant cognitive deficits (as indicated by a score of 22 or lower on the Thai Mental State Examination [Department of Mental Health, 2011b]); (5) history of loss of consciousness or post-traumatic amnesia at the time of injury; (6) skull defects that would interfere with tDCS treatment; and (7) contraindications for undergoing an MRI scan, i.e., patients who have a heart pacemaker, a metallic foreign body (metal sliver) in their eye, or an aneurysm clip in their brain, severe claustrophobia.

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