Genes, Omega-3 Fatty Acids and Cardiovascular Disease Risk Factors
Not Applicable
Active, not recruiting
- Conditions
- Cardiovascular Disease
- Interventions
- Dietary Supplement: n-3 PUFA supplementation
- Registration Number
- NCT01343342
- Lead Sponsor
- Laval University
- Brief Summary
The main purpose of this study is to examine whether n-3 PUFA-induced changes in metabolic risk factors are influenced by genetic variations within genes acting as fatty acids sensors.
- Detailed Description
The main purpose of this study is to examine whether n-3 PUFA-induced changes in metabolic risk factors are influenced by genetic variations within genes acting as fatty acids sensors. To do so, the metabolic risk factor response to an n-e PUFA supplementation will be compared in carriers and non-carriers of polymorphism within genes acting as fatty acids sensors.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 200
Inclusion Criteria
- healthy men and women aged between 18 to 50 years;
- having a BMI between 25 and 40kg/m2;
- plasma triglycerides levels <4.0 mmol/L;
- non-smokers;
- free of any thyroid or metabolic disorders requiring treatment such as diabetes, hypertension, severe dyslipidemia, and coronary heart disease.
Exclusion Criteria
- subjects taking medication for hyperlipidemia, hypertension, diabetes or taking anticoagulant or n-3 PUFA supplementation;
- having a taste aversion for fish, fish allergy or regular alcohol drinker;
- body mass index > 40kg/m2;
- pregnant or nursing women.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description capsules omega-3 n-3 PUFA supplementation Omega-3 supplementation (3g EPA+DHA/d)
- Primary Outcome Measures
Name Time Method Change in blood lipids (Total cholesterol, HDL-Cholesterol, Triglycerides) Before and after a 6-weeks supplementation
- Secondary Outcome Measures
Name Time Method Change in anthropometric measures (waist and hip girth) Before and after a 6-weeks supplementation Change in blood pressure Before and after a 6-weeks supplementation Change in plasma glycemia and insulin levels Before and after a 6-weeks supplementation Change in gene expression levels Before and after a 6-weeks supplementation
Trial Locations
- Locations (1)
Institute of Nutraceutical and Functional Foods (INAF), Laval University
🇨🇦Quebec, Canada