Genes, Omega-3 Fatty Acids and Cardiovascular Disease Risk Factors

Not Applicable

Active, not recruiting

• Conditions: Cardiovascular Disease

• Registration Number: NCT01343342
• Lead Sponsor: Laval University

Brief Summary

The main purpose of this study is to examine whether n-3 PUFA-induced changes in metabolic risk factors are influenced by genetic variations within genes acting as fatty acids sensors.

Detailed Description

The main purpose of this study is to examine whether n-3 PUFA-induced changes in metabolic risk factors are influenced by genetic variations within genes acting as fatty acids sensors. To do so, the metabolic risk factor response to an n-e PUFA supplementation will be compared in carriers and non-carriers of polymorphism within genes acting as fatty acids sensors.

Study Timeline

• Study Start: 2009-10
• Study First Submitted: 2011-04-21
• Study First Submitted QC: 2011-04-27
• Study First Posted: 2011-04-28
• Primary Completion: 2011-12
• Status Verified: 2024-11
• Last Update Submitted: 2024-11-05
• Last Update Posted: 2024-11-06
• Study Completion: 2026-03

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• healthy men and women aged between 18 to 50 years;
• having a BMI between 25 and 40kg/m2;
• plasma triglycerides levels <4.0 mmol/L;
• non-smokers;
• free of any thyroid or metabolic disorders requiring treatment such as diabetes, hypertension, severe dyslipidemia, and coronary heart disease.

Exclusion Criteria

• subjects taking medication for hyperlipidemia, hypertension, diabetes or taking anticoagulant or n-3 PUFA supplementation;
• having a taste aversion for fish, fish allergy or regular alcohol drinker;
• body mass index > 40kg/m2;
• pregnant or nursing women.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Change in blood lipids (Total cholesterol, HDL-Cholesterol, Triglycerides)	Before and after a 6-weeks supplementation

Secondary Outcome Measures

Name	Time	Method
Change in anthropometric measures (waist and hip girth)	Before and after a 6-weeks supplementation
Change in plasma glycemia and insulin levels	Before and after a 6-weeks supplementation
Change in gene expression levels	Before and after a 6-weeks supplementation
Change in blood pressure	Before and after a 6-weeks supplementation

Trial Locations

Locations (1)

Institute of Nutraceutical and Functional Foods (INAF), Laval University; 🇨🇦 Quebec, Canada