How to Improve Diagnosis in Infective Endocarditis

Completed

• Conditions: Endocarditis, Bacterial

• Registration Number: NCT00524212
• Lead Sponsor: University of Aarhus

Brief Summary

The purpose is to exam prospective if simple clinical information in combination with a normal s-procalcitonin are sufficient for exclusion of infective endocarditis (IE).

Detailed Description

Despite progress in surgical and medical treatment, infective endocarditis is still associated with high morbidity and mortality.

The variable clinical presentation of IE makes the diagnosis a clinical challenge.

Procalcitonin is a precursor from the hormone calcitonin and also a marker of systemic bacterial infections.

The purpose of this study is:

* to investigate the diagnostic value of serum procalcitonin (PCT), C-reactive protein (CRP) and sedimentation rate (SR) when IE is suspected.

* to investigate if a retrospectively generated clinical model suitable for exclusion of IE can be confirmed prospectively.

Study Timeline

• Study Start: 2007-03
• Study First Submitted: 2007-08-31
• Study First Submitted QC: 2007-08-31
• Study First Posted: 2007-09-03
• Study Completion: 2009-05
• Status Verified: 2010-01
• Last Update Submitted: 2010-01-19
• Last Update Posted: 2010-01-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 761

Inclusion Criteria

• Patients > or = 18 year with suspected or verified Infective Endocarditis
• By word of mouth or in writing consent

Exclusion Criteria

• Incapacity

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Department of Cardiology, Aarhus University Hospital; 🇩🇰 Aarhus, Denmark