The Role of Long Non-coding RNAs WRAP53 and UCA-1 as Potential Biomarkers in Diagnosis of Hepatocellular Carcinoma
试验速览
- 阶段
- 不适用
- 入组人数
- 80
- 试验地点
- 2
- 主要终点
- Diagnostic value of long non coding RNA UCA-1 and WRAP53 in Hepatolcellular carcinoma
研究概览
简要总结
The aim of this work is to study the role of long non-coding RNAs WRAP53 and urothelial carcinoma-associated 1 (UCA1) as potential biomarkers in diagnosis of hepatocellular carcinoma.
详细描述
Sample size calculation was done in department of medical statistics, Medical Research Institute, Alexandria University and the total minimal sample size was calculated.
A prospective case control study will be conducted on 80 subjects divided into three groups:
Group (1): Thirty patients having liver cirrhosis and hepatocellular carcinoma diagnosed by tripahsic CT.
Group (2): Thirty liver cirrhosis patients without hepatocellular carcinoma diagnosed by abdominal ultrasound examination.
Group (3): Twenty normal subjects (control group) matching in age and sex with patients in groups 1 and 2.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Any subject without any of the exclusion criteria
排除标准
- •Patients with any inflammatory diseases or other malignancies.
结局指标
主要结局
Diagnostic value of long non coding RNA UCA-1 and WRAP53 in Hepatolcellular carcinoma
时间窗: One year
Calculating sensitivity and specifity of UCA-1 and WRAP53 to assess their diagnostic value in diagnosis of hepatocellular carcinoma
次要结局
未报告次要终点
研究者
Elsheaita, Ahmed Mohamed Elmoughazy Abdelfatah Aly
Assistant lecturer, experimental and clinical internal medicine, medical research institute
Alexandria University