Asking People With Psoriasis About Lifestyle and Eating
- Conditions
- Psoriasis
- Registration Number
- NCT05448352
- Lead Sponsor
- King's College London
- Brief Summary
The APPLE Study aims to understand if specific diet and lifestyle patterns are present in individuals with psoriasis and if these factors are correlated with psoriasis severity.
- Detailed Description
Prospective participants will be invited to read an information sheet and provide informed consent. Once informed consent is obtained, participants will be screened for eligibility with a short online screening questionnaire. Upon successful completion, participants will be directed to start the online multiple-choice survey with questions on psoriasis, diet and lifestyle patterns and complete a 4-day diet diary.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 358
Adults (18 years of age or older) Dermatologist diagnosis of psoriasis Residents in the United Kingdom (UK) Fluent in English
Minors (17 years of age or younger) Not medically diagnosed with Psoriasis Non-UK residents
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The Dermatology Life Quality Index (DLQI) Baseline This index measures the impact of psoriasis on day-to-day routines as well as on psychological and social fronts. Responses to questions are scored as follows: very much (3 points), a lot (2 points), a little (1 point), not at all/not relevant (0 points).
The DLQI provides a score between 0-30. The score range is interpreted as follows: 0-1 points = no effect at all on the participants life, 2-5 points = small effect on participant's life, 6-10 points = moderate effect on participant's life, 11-20 = very large effect on participant's life and 21-30 = extremely large effect on participant's life.self-assessed Simplified Psoriasis Index Baseline The self-assessed Simplified Psoriasis Index measures psoriasis severity as a joint score of 3 categories.
Severity; a 3-point scale will measure the severity of skins lesions on 10 body parts. 0=minimal, +/-=noticeable. + =extensive. A 5-point scale ranging from 0=clear to 5=intensely inflamed skin will measure the overall state of psoriasis.
Psychosocial; a 10 point scale ranging from 0=not at all to 10=very much will indicate the extent to which psoriasis is affecting day-to-day life.
Intervention; participants will need to indicate each psoriasis treatment that is being received. 1 point per treatment.
The sa-PSI will generate a total score out of 70. The higher the score, the greater the severity of psoriasis.Diet 4 day 24-hour dietary recall Nutrient consumption will be examined using the Intake24 (https://intake24.co.uk/). This is dietary assessment tool in which participants will record their food intake over the past 24 hours. The results obtained from the Intake24 will provide a detailed breakdown of the total calories, macronutrients and micronutrients consumed.
- Secondary Outcome Measures
Name Time Method Meal timings Baseline Meal timings will be captured using the Food Timing Questionnaire.
Smoking Baseline Smoking status will be evaluated as smoker, non-smoker or ex-smoker.
Sleep Baseline Questions from the Pittsburgh Sleep Quality Index will be used to evaluate sleep quality, latency and duration.
Sleep quality: is measured on a 4-point scale ranging from very bad to very good.
Sleep latency: participants will indicate the number of minutes taken to fall asleep on a weekday and weekend day. The 6-point scale ranges from 0-10 minutes to 60+ minutes.
Sleep duration: participants will indicate the number of hours of actual sleep that are obtained on a weekday/weekend day.Alcohol Baseline The frequency and units of alcohol intake will be examined using the Alcohol Use Disorders Identification Test Consumption (AUDIT-C).
Demographic characteristics Baseline The demographic characteristics assessed include age, gender and ethnicity.
Physical Activity (PA) Baseline The International Physical Activity Questionnaire (IPAQ) categorises PA into vigorous intensity, moderate intensity and walking. The frequency (number of days/week) and the duration (number of hours) for each PA category will determine the participant's PA level:
Health Enhancing Physical Activity (HEPA)=vigorous intensity physical activity is undertaken on at least 3 days/ week with a minimum of 1500 metabolic equivalent (MET) minutes/week or with 7 or more days of any combination of walking, moderate or vigorous intensity activities with a minimum of 3000 MET minutes/week.
Minimally active (any one of the following)=3 or more days of vigorous activity with at least 20 minutes/day, 5 or more day of moderate intensity or walking at least 30 minutes/day, or 5 or more days of combination of walking, moderate or vigorous intensity activities with a minimum of 600 MET minutes/week.
Inactive=no activity is reported or if some activity is reported but does not meet the above criteria.Dietary habits Baseline Dietary habits will be evaluated based on the inclusion and exclusion of food items from diet, beliefs around diets and following specific diets as means to improve psoriasis.
General Health Baseline General health will be examined based on the presence of health conditions such as obesity, cardiovascular disease, diabetes etc.
Trial Locations
- Locations (1)
King's College London
🇬🇧London, United Kingdom