FOLFIRI + panitimumab first-line treatment of metastatic colorectal cancer in elderly patients with good performance status

Phase 1

• Conditions: First-line treatment in elderly patients with RAS/BRAF wild-type unresectable metastatic colorectal cancer and good performance status; MedDRA version: 20.0Level: LLTClassification code 10052362Term: Metastatic colorectal cancerSystem Organ Class: 100000004864; Therapeutic area: Diseases [C] - Cancer [C04]

• Registration Number: EUCTR2017-001639-38-ES
• Lead Sponsor: Grupo Español Multidisciplinar en Cáncer Digestivo (GEMCAD)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-06-09
• Last Update Posted: 21 August 2017

Recruitment & Eligibility

• Status: Authorised-recruitment may be ongoing or finished
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1) Males or females = 70 years
2) Able to understand, sign and date an informed consent form approved by the IEC
3) Histologically confirmed colorectal carcinoma with unresectable metastatic disease
4) RAS/BRAF wild-type status in solid biopsy confirmed prior to inclusion of the study
5) No previous treatment for metastatic disease
6) Patients starting therapy with FOLFIRI + panitumumab with a treatment aim other than achieving potential resectability of the disease
7) Independence in activities of daily living (ADL) based on the Katz Index and in instrumental activities of daily living (IAL) based on the Lawton Index
8) Having no or only one comorbidity according to the Charlson Comorbidity Index
9) Presence of at least one unidimensional measurable lesion = 20 mm according to RECIST criteria (version 1.1)
10) ECOG (Eastern Cooperative Oncology Group) performance status of 0-1
11) Adequate bone marrow function: neutrophils = 1.5 x 10^9/l; platelets = 100 x 10^9/l; haemoglobin = 9 g/dl
12) Hepatic, renal and metabolic function as follows:
a) Total bilirubin count = 1.5 x ULN; ALT and AST < 5 x ULN;
b) Renal function, calculated creatinine clearance or 24-hour creatinine clearance = 50 ml/min;
c) Magnesium > LLN
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) no
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range 80

Exclusion Criteria

1) Diagnosed or suspected central nervous system (CNS) metastasis
2) History or presence of another malignancy, with the exception of curatively treated in situ carcinoma of the cervix or non-melanoma skin cancer or any curatively treated solid tumour, with no active disease or administration of treatment within 5 years prior to inclusion in the study
3) Prior treatment with irinotecan
4) Prior adjuvant chemotherapy for colorectal cancer terminated less than 6 months before metastatic disease was diagnosed
5) Prior anti-epidermal growth factor receptor (EGFR) antibody therapy (eg, cetuximab), anti- vascular endothelial growth factor (VEGF) or treatment with small molecule EGFR inhibitors (eg, erlotinib)
6) Unresolved toxicities from prior systemic treatment that, in the investigator's opinion, make the patient unsuitable for inclusion
7) Hormone therapy, immunotherapy with experimental or approved antibodies/proteins (e.g. bevacizumab) = 30 days prior to inclusion
8) Evidence of previous acute hypersensitivity reaction of any grade to any of the components of the treatment
9) History of interstitial lung disease or pulmonary fibrosis or signs of interstitial lung disease or pulmonary fibrosis on baseline CT
10) Presence of geriatric syndromes, defined as dementia, repeated falls, fecal incontinence or urinary incontinence
11) Acute or subacute bowel obstruction and/or active bowel disease or another bowel disease causing chronic diarrhoea (defined as diarrhoea of grade = 2 according to the NCI (National Cancer Institute) Common Terminology Criteria for Adverse Events (CTCAE version 4.03)
12) Significant cardiovascular disease, including unstable angina pectoris or myocardial infarction within 12 months prior to inclusion in the study
13) History of Gilbert's syndrome or dihydropyrimidine dehydrogenase deficiency
14) Positive test result for human immunodeficiency virus, hepatitis C virus, chronic active hepatitis B infection
15) Treatment for systemic infection within 14 days prior to the start of the study treatment
16) Clinically significant sensory peripheral neuropathy
17) Any concurrent disease that may increase the risk associated with study participation or may interfere with the interpretation of study results
18) Any investigational product within 30 days prior to inclusion
19) Surgery (not including diagnostic biopsy or the placement of a central line) and/or radiotherapy within 28 days prior to inclusion in the study
20) Males whose partner is of child-bearing age and who does not agree to use adequate contraceptive precautions, i.e. double-barrier methods (e.g. diaphragm plus condom) or abstinence for the duration of the study and for 1 month after the last administration of the study drug
21) Subjects who do not agree or are unable to meet the study requirements
22) Psychological, familial, sociological or geographical conditions potentially hampering compliance with the study protocol and the follow-up schedule. Such conditions should be discussed with the patient before enrolment in the clinical trial

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified