ISRCTN70332574
Completed
N/A
Protective ventilation during general anaesthesia for open abdominal surgery: a randomised controlled trial
Academic Medical Centre (AMC) (Netherlands)0 sites900 target enrollmentDecember 6, 2010
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Academic Medical Centre (AMC) (Netherlands)
- Enrollment
- 900
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Planned elective abdominal surgery
- •2\. General anaesthesia with intravenous medication
- •3\. High or intermediate risk for post\-operative pulmonary complications
- •4\. Aged greater than or equal to 18 years, either sex
Exclusion Criteria
- •1\. Aged less than 18 years
- •2\. Body mass index greater than 40 kg/m^2
- •3\. Laparoscopic surgery
- •4\. Previous lung surgery (any)
- •5\. Persistent haemodynamic instability, intractable shock (considered haemodynamic unsuitable for the study by the patient's managing physician)
- •6\. History of previous severe chronic obstructive pulmonary disease (COPD) (non\-invasive ventilation and/or oxygen therapy at home, repeated systemic corticosteroid therapy for acute exacerbations of COPD)
- •7\. Recent immunosuppressive medication (patients receiving chemotherapy or radiation therapy within the last 2 months)
- •8\. Severe cardiac disease (New York Heart Association class III or IV, or acute coronary syndrome, or persistent ventricular tachyarrhythmia's)
- •9\. Mechanical ventilation greater than than 30 minutes (e.g., in cases of general anaesthesia because of surgery) within last 30 days
- •10\. Pregnancy (excluded by laboratory analysis)
Outcomes
Primary Outcomes
Not specified
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