MedPath

Aging of the Vascular Wall

Not yet recruiting
Conditions
Vascular Risk
Aging Disorder
Registration Number
NCT07122427
Lead Sponsor
Centre Hospitalier Universitaire de Saint Etienne
Brief Summary

Demographic aging is predicted to be one of the most significant social changes of the 21st century. Aging is a slow, multifactorial process that progressively impacts the integrity of cells, tissues, and organs. This decline in function increases the risk of numerous diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases (CVD). CVD, the leading global cause of death, becomes more prevalent with age. Aging contributes to endothelial dysfunction, vessel stiffness, thickening, and impaired platelet function. These changes disrupt hemostatic processes and increase the risk of cardiovascular complications. Despite preventive strategies CVD remain a major public health challenge. Cellular aging, or senescence, affects all cell types, particularly endothelial cells and platelets. However, little research has compared the aging rates of different blood vessel types, such as arteries and veins. Given their distinct compositions and developmental origins, it is likely that their aging processes differ at molecular, cellular, and physiological levels.

Detailed Description

Not available

Recruitment & Eligibility

Status
NOT_YET_RECRUITING
Sex
All
Target Recruitment
30
Inclusion Criteria
  • Major patients requiring coronary artery bypass grafting (CABG).
Exclusion Criteria
  • Hypertension, diabetes, systemic inflammatory disease.

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Biomarkers of ageingDay 1

Microscope analysis of the arterial and venous wall samples from donors requiring surgery for myocardial revascularization.

Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (1)

CHU Saint-Etienne

🇫🇷

Saint-Etienne, France

CHU Saint-Etienne
🇫🇷Saint-Etienne, France
Anne-Claire DUCHEZ, PhD
Sub Investigator
Salvatore CAMPISI, MD
Principal Investigator

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