Efficacy and Safety of Catheter Ablation of Atrial Fibrillation in Patients With Thyroid Hormone Stabilization
- Conditions
- HyperthyroidismHypothyroidismAtrial Fibrillation and Flutter
- Interventions
- Procedure: Catheter Ablation
- Registration Number
- NCT06452823
- Lead Sponsor
- The Second Affiliated Hospital of Jiaxing University
- Brief Summary
Patients with hyperthyroidism or hypothyroidism are often combined with atrial fibrillation, but after the stabilization of thyroid hormone levels after treatment, the patients' atrial fibrillation still persists. Radiofrequency ablation of the atrial fibrillation as one of the treatment options for atrial fibrillation has been widely used in the clinic, and has significant efficacy in maintaining sinus rhythm, improving cardiac function, and improving the prognosis of patients. However, there is a lack of clinical monitoring data on radiofrequency ablation of atrial fibrillation in patients who have combined thyroid dysfunction and have stabilized their thyroid hormone levels after treatment.
- Detailed Description
In patients recommended by guidelines for atrial catheter radiofrequency ablation of atrial fibrillation, catheter radiofrequency ablation was performed after exclusion of contraindications, and was observed and compared between patients with comorbid pre-existing thyroid hormone disorders and patients without comorbid atrial fibrillation after radiofrequency ablation:1: time to sexual rhythm maintenance: incidence of cardiac-related complications and incidence of noncardiac-related complications within 3 months and 1 year,2: walking distance on a six-minute walk test within 3 months,1 year, comparison of percent left ventricular ejection fraction, and comparison of left ventricular diastolic diameter at the time 3 months,1 year,.To comprehensively assess the efficacy and safety of catheterized radiofrequency ablation of atrial fibrillation in patients with comorbidities of prior thyroid hormone disorders.
Recruitment & Eligibility
- Status
- ENROLLING_BY_INVITATION
- Sex
- All
- Target Recruitment
- 200
Atrial Fibrillation Requiring Catheterized Radiofrequency Ablation （Class I Recommendation）
Atrial Fibrillation Requiring Catheterized Radiofrequency Ablation Class I Recommendation With Coexisting Contraindications
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Combined Thyroid Dysfunction Catheter Ablation Atrial catheter radiofrequency ablation for atrial fibrillation combined with patients requiring prior thyroid hormone abnormalities Uncomplicated thyroid dysfunction Catheter Ablation Atrial catheter radiofrequency ablation for atrial fibrillation in patients with uncomplicated need for prior thyroid hormone abnormalities
- Primary Outcome Measures
Name Time Method Postoperative heart-related complications 3 month and 1year after cardiac radiofrequency ablation Cardiac perforation/cardiac tamponade Coronary artery stenosis/occlusion Pericarditis Atrial stiffness syndrome Coronary artery air embolism Pseudoaneurysm Severe pulmonary stenosis
Non-Cardiac Related Complications 3 month and 1year after cardiac radiofrequency ablation Neurological Complications Asymptomatic cerebral embolism TIA Perioperative stroke Permanent phrenic nerve injury Digestive Complications Esophageal Injury Gastric Hyperdynamics Atrioesophageal Fistula Vascular Complications Hematoma Arteriovenous fistula Pseudoaneurysm Severe pulmonary stenosis
Recurrence of atrial fibrillation Recurrence of atrial fibrillation Recurrence of atrial fibrillation Recurrence of atrial fibrillation Recurrence of atrial fibrillation Recurrence of atrial fibrillation Recurrence of atrial fibrillation 3 month and 1year after cardiac radiofrequency ablation Inability to maintain sinus rhythm, recurrent atrial fibrillation or atrial flutter
- Secondary Outcome Measures
Name Time Method 6-minute walk test 3 month and 1year after cardiac radiofrequency ablation Left atrial diastolic diameter
Left Atrial Internal Diameter 3 month and 1year after cardiac radiofrequency ablation Left atrial anteroposterior and superior-inferior diameters
LVEF% 3 month and 1year after cardiac radiofrequency ablation Per-beat output as a percentage of ventricular end-diastolic volume (cardiac preload)
Trial Locations
- Locations (1)
Cardiovascular Medicine Department of Second Affiliated Hospital of Jiaxing University
🇨🇳Jiaxing, Zhejiang, China