Emergency Versus Elective Cholecystectomy in Acute Cholecystitis in the Era of Laparoscopy.

Not Applicable

• Conditions: Cholecystitis, Acute
• Interventions: Procedure: Laparoscopic cholecystectomy

• Registration Number: NCT05502744
• Lead Sponsor: Assiut University

Brief Summary

The aim of study is compare outcome of patients undergoing early laparoscopic cholecystectomy within 72 hours from the begging of symptoms to those of patients managed conservatively and operated late after 6-8weeks after the inflammatory reaction has subsided.

Detailed Description

Acute cholecystitis is considered one of the most common acute surgical problems. It includes typical symptoms of pain in right hypochondrium, fever, increased leucocytes count and abdominal US used to confirm this clinical diagnosis. Laparoscopic cholecystectomy (LC) is the standard treatment for acute cholecystitis due to the advantages of small wounds, less use of abdominal drains , less need for antibiotics and analgesics and less postoperative hospital stay time.Laparoscopic cholecystectomy in acute cholecystitis may be performed as soon as begging of the symptoms called emergency or urgent laparoscopic cholecystectomy and maybe scheduled in advance after controlling acute attack after 6-8weeks called elective laparoscopic cholecystectomy . Emergency laparoscopic cholecystectomy has advantage of a decreased hospital stay and avoids the risk of emergency admission for non-resolved or recurrent symptoms, which is associated with an increase in morbidity, pain and delayed return to work. Also, some trials showed increased morbidity with elective laparoscopic cholecystectomy mostly due to biliary disease while patients await surgery. Comparative studies are deficient in evaluation of outcomes of emergency cholecystectomy and elective cholecystectomy in acute cholecystitis. So the interest of our study is to compare between the emergency laparoscopic cholecystectomy and elective laparoscopic cholecystectomy regarding the feasibility and the safety of the first.

Study Timeline

• Status Verified: 2022-08
• Study First Submitted: 2022-08-06
• Study First Submitted QC: 2022-08-13
• Last Update Submitted: 2022-08-13
• Study Start: 2022-08-14
• Study First Posted: 2022-08-16
• Last Update Posted: 2022-08-16
• Primary Completion: 2022-09-14
• Study Completion: 2023-08-14

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

1. age less than 70 years.
2. fit for surgery.

Exclusion Criteria

1. patients with co-existent common bile duct stones based on imaging and biochemical criteria.
2. Patients with Pancreatitis .
3. Patients with previous upper abdominal surgery.
4. Significant medical disease rendering patient unfit for Laparoscopic surgery (e.g.Chronic Pulmonary Disease, significant Cardiac Disease)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Emergency Versus Elective Cholecystectomy in Acute Cholecystitis in the Era of Laparoscopy	Laparoscopic cholecystectomy	A Prospective Randomized Comparative Study.

Primary Outcome Measures

Name	Time	Method
Incidence of intraoperative complications in urgent versus elective lap cholecystostomy.	Intraoperative time	Collect results and see.

Secondary Outcome Measures

Name	Time	Method
Incidence of postoperative complications in urgent versus elective lap cholecystectomy.	6 months.	Collect results and see.