Influence of Escitalopram on the incidence of depression and dementia following acute middle cerebral artery territory infarction. A randomized, placebo-controlled, double blind study. - Poststroke Depression

Central Institute for Mental Health, Mannheim, Div. of Gerontopsychiatry0 个研究点目标入组 60 人开始时间: 2006年1月4日最近更新: 2012年3月19日

适应症

试验速览

暂无简介。

•an acute MCA territory infarction
•over the age of = 18 years
•Can be included into this study within 7 days after onset of the stroke
•an estimated pre-morbid Rankin Scale (RS) score = 2
•The subject must be prepared to and considered able to follow the protocol during the whole trial period and to attend the planned visits, even if the treatment has to be withdrawn.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range

•a history of dementia
•a history of recurrent major depression
•a history of major stroke
•alcohol or drug dependency
•any systemic disease, which can influence his/her safety and compliance, or the evaluation of the disability
•a woman who is pregnant, breast-feeding or have the possibility for pregnancy during the study. To avoid pregnancy, women have to be menopausal, surgical sterile, sexually inactive or practice reliable contraceptives
•any other medical reason at the discretion of the treating physician
•participation in any other studies, involving other investigational products, within 30 days prior to participating in this trial
•concomitant medication with MAO-inhibitors, triptans, tramaldol, other antidepressants, or lithium
•creatinine-clearance <20ml/min or serum creatinine >2,4mg/dl
•an impaired liver function (abnormal CHE or Bilirubin >2,0mg/dl)
•an estimated life expectancy <6 months

发起方

Central Institute for Mental Health, Mannheim, Div. of Gerontopsychiatry