An Open-Label, Single-Dose Study to Evaluate the Effects of Age and Sex on the Pharmacokinetics of Apremilast (CC-10004) in Healthy Subjects

Amgen2 sites in 1 country36 target enrollmentFebruary 1, 2012

ConditionsHealthy Volunteer

InterventionsApremilast

DrugsApremilast

Overview

Phase: Phase 1
Intervention: Apremilast
Conditions: Healthy Volunteer
Sponsor: Amgen
Enrollment: 36
Locations: 2
Primary Endpoint: Maximum Observed Plasma Concentration of Apremilast by Sex
Status: Completed
Last Updated: 5 years ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of the study is to evaluate the effects of age and sex on the pharmacokinetics and safety of a single oral dose of 30 mg apremilast in healthy adults.

Detailed Description

This is an open-label, parallel group study where eligible elderly adults (aged 65-85 years inclusive) and younger adults (aged 18-55 years inclusive) and who are matched to the elderly participants by sex and body mass index (BMI) (± 10%) will receive a single dose of 30 mg apremilast under fasting conditions.

Registry

clinicaltrials.gov

Start Date

February 1, 2012

End Date

April 1, 2012

Last Updated

5 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Amgen

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Inclusion Criteria for elderly group
•Healthy male or female subjects of any ethnic origin between ages of 65 and 85 inclusive with a body mass index (BMI) between 18 and
•Females must have been surgically sterilized at least 6 months prior to screening or be postmenopausal (to be confirmed by lab tests).
•Males must agree to use latex or polyurethane condoms when engaging in sex during the study and for at least 28 days after dosing.
•Elderly subjects with stable, chronic medical condition may be eligible if the condition is well-controlled and medications do not interfere with study procedures or pharmacokinetic interpretation
•Inclusion Criteria for younger group:
•Healthy male or female of any ethnic origin between the ages of 18 and 55 inclusive with a BMI between 18 and
•Males must agree to use latex or polyurethane condoms when engaging in sex during the study and for at least 28 days after dosing.
•Females who are able to become pregnant have a negative pregnancy test at screening and baseline, and must agree to use one of the following:
•a highly effective form of contraception (ex. Non-oral hormonal, intrauterine device) OR

Exclusion Criteria

•Any condition, including the presence of laboratory abnormalities, or psychiatric illness, that would prevent the subject from signing the Informed Consent form, places the subject at unacceptable risk if he were to participate in the study, or confounds the ability to interpret data from the study.
•Presence of any surgical or medical conditions possibly affecting drug absorption, distribution, metabolism, and excretion, or plans to have elective or medical procedures during the conduct of the trial.
•Exposure to an investigational drug (new chemical entity) within 30 days prior to the first dose administration or 5 half-lives of that investigational drug, if known (whichever is longer).
•Subjects with known serum hepatitis, is a known carrier of hepatitis B surface antigen, hepatitis C antibody, or human immunodeficiency virus antibody.
•Subjects who have used prescription systemic or topical medications within 30 days of dosing, unless it is being used to treat a stable, chronic medical condition. This includes medication that is an inhibitor or inducer of P-glycoprotein transporter and CYP-3A4/5 used within 14 days of dosing.

Arms & Interventions

Elderly: Apremilast 30 mg

Participants aged 65 to 85 years received a single oral dose of 30 mg apremilast on Day 1.

Intervention: Apremilast

Younger: Apremilast 30 mg

Participants aged 18 to 55 years received a single oral dose of 30 mg apremilast on Day 1.

Intervention: Apremilast