To compare the effectiveness of oral itraconazole with low dose and high dose isotretinoin in the treatment of tinea

Not yet recruiting

• Conditions: Dermatophytosis, unspecified,

• Registration Number: CTRI/2019/06/019600
• Lead Sponsor: Department of dermatology

Brief Summary

Dermatophytosis is caused by mainly Trichophyton , Epidermophyton and MIcrosporum affecting more than 20- 25% of world’s population. Recently there has been an alarming rise in the number of dermatophytosis patients as well as the recalcitrant cases .

The recent change in the dermatophyte infection has resulted in a change in its response to treatment as well. The conventional systemic agents like griseofulvin , ketoconazole , fluconazole and even the newer synthetic agents like itraconazole , terbinafine are no longer effective as they were initially .

The present study is being designed to assess the role of isotretinoin in low and high dose as an adjuvant along with oral itraconazole in treatment of dermatophytosis. It aims to find whether patients treated with this combination have better efficacy and less treatment failures .

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2019-06-06
• Study Start: 2019-06-15

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• KOH positivity on direct microscopy showing septate hyphae of dermAtophytosis .
• Patients with extensive disease requiring systemic therapy .
• Patients above 18 years of age .

Exclusion Criteria

• Patients with co-existing dermatophytosis involving hairs, nail, palms and soles.
• Patients with hepatic , renal derangement , abnormal lipidvprofile or any significant systemic illness.
• Patients on immunosuppressive agents.
• Pregnant and lactating women .
• Women of child bearing age not using contraception indicated for systemic retinoids therapy .

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Compare the therapeutic efficacy of concomitant use of low and high dose isotretinoin along with itraconazole in dermatophytosis	0,2,4,8 weeks

Secondary Outcome Measures

Name	Time	Method
To look for adverse effects of combination of Itraconazole and Isotretinoin	0,2,4,8 weeks

Trial Locations

Locations (1)

Government Medical College and Hospital; 🇮🇳 Chandigarh, CHANDIGARH, India

Government Medical College and Hospital

🇮🇳Chandigarh, CHANDIGARH, India

Dr Shradha

Principal investigator

7837398348

jshradha2492@gmail.com