Pegzilarginase and Pembrolizumab for Extensive Disease Small Cell Lung Cancer

Phase 1

Completed

• Conditions: Small-cell Lung Cancer
• Interventions: Drug: Pegzilarginase; Drug: Pembrolizumab

• Registration Number: NCT03371979
• Lead Sponsor: Aeglea Biotherapeutics

Brief Summary

The main purpose of this Phase 1/2 study is to determine the safety and efficacy of pegzilarginase in combination with pembrolizumab in patients with ED-SCLC who have relapsed or progressive disease on or within 6 months of platinum-based chemotherapy.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2017-11-20
• Study First Submitted QC: 2017-12-08
• Study First Posted: 2017-12-13
• Study Start: 2017-12-21
• Primary Completion: 2021-01-01
• Study Completion: 2021-01-01
• Status Verified: 2021-11
• Last Update Submitted: 2021-11-03
• Last Update Posted: 2021-11-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 68

Inclusion Criteria

1. Patient is able and willing to provide written informed consent

2. Be > 18 years of age on day of signing informed consent

3. Have histologically or cytologically confirmed SCLC that meets:

   1. Extensive disease per criteria of the International Association for the Study of Lung Cancer (IASLC)-American Joint Committee on Cancer (AJCC) TNM staging system
   2. Have not tolerated or have progressed or relapsed on or within 6 months of platinum-based chemotherapy

4. Have a performance status of ≤ 1 on the ECOG Performance Scale

5. Have measurable disease based on RECIST 1.1

6. Willing to undergo core needle or incisional biopsy to obtain fresh tumor tissue specimens

7. Demonstrate adequate organ function as evidenced by laboratory testing with specimens collected within 10 days prior to day 1 of cycle 1

8. Female child-bearing potential must have a negative urine or serum pregnancy test within 72 hours prior to receiving the first dose of study medication

9. Sexually active male or female must be surgically sterile post-menopausal, or must agree to use a physician-approved method of birth control during the study through a minimum of 120 days after the last study drug administration.

Key

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Exclusion Criteria

1. Has received more than 2 platinum-based regimens against SCLC
2. Has received pembrolizumab, or prior therapy with an anti-PD-1, anti-PD-L1, anti-PD-L2, or anti-Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) antibody as part of any previous therapy, including trials
3. Has participated in Merck MK-3475 (pembrolizumab) clinical trials
4. Has received pegzilarginase as part of any previous therapy
5. Is currently participating in a study of an investigational agent or received the last dose of an investigational agent within 4 weeks prior to the first dose of treatment in this study (a shorter interval for kinase inhibitors or other short half-life drugs could be considered after approval from the Sponsor). Is currently participating in a study of an investigational device within 4 weeks of the first dose of treatment
6. Has a diagnosis of an immunodeficiency, is receiving systemic steroid therapy (except for physiological dose levels), or immunosuppressive therapies
7. Has a known additional malignancy that is progressing or has required active treatment within the past 3 years. Exceptions include basal cell carcinoma of the skin, squamous cell carcinoma of the skin, or carcinoma in situ (e.g. breast carcinoma, cervical cancer) that has undergone potentially curative therapy
8. Has known central nervous system (CNS) metastases. However, patients with previously treated brain metastases may participate provided neurologic symptoms have stabilized, there is no evidence of new brain metastases or hemorrhage and they are not using steroids for brain metastases or for complications derived from their treatment for at least 7 days prior to the first dose of trial treatment
9. Has known carcinomatous meningitis
10. Has an active autoimmune disease requiring systemic treatment in the past 2 years (i.e. with use of disease modifying agents, corticosteroids or immunosuppressive drugs) or a documented history of clinically severe autoimmune disease, or a syndrome that requires systemic steroids or immunosuppressive agents. Patients with vitiligo or resolved childhood asthma/atopy are an exception to this rule. Patients that require intermittent use of bronchodilators or local steroid injections will not be excluded from the study. Patients with hypothyroidism stable on hormone replacement or Sjorgen's syndrome will not be excluded from the study. Replacement therapy (e.g. thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc) is not considered a form of systemic treatment
11. Has evidence of interstitial lung disease, history of non-infectious pneumonitis that required steroids, or current pneumonitis
12. Inadequately controlled hypertension (defined as systolic blood pressure ≥ 200 mmHg and/or diastolic blood pressure ≥ 120 mmHg) on more than one occasion in the month before planned day of infusion
13. Currently taking 3 or more anti-hypertensive medications
14. Prior history of hypertensive crisis or hypertensive encephalopathy
15. History of myocardial infarction, unstable angina, cardiac or other vascular stenting, angioplasty, or cardiac or vascular surgery within 6 months prior to day 1 of study treatment
16. Is pregnant or breastfeeding, or expecting to conceive or father children within the projected duration of the trial, starting with the pre-screening or screening visit through 120 days after the last dose of trial treatment
17. Has a known history of Human Immunodeficiency Virus (HIV) (positive for HIV p24 antigen or HIV 1/2 antibodies)
18. Has known active Hepatitis B (e.g., HBsAg reactive) or Hepatitis C (e.g., HCV RNA [qualitative] is detected)
19. Has a known history of active tuberculosis (Bacillus tuberculosis)
20. Has had an allogenic tissue/solid organ transplant.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Pegzilarginase plus Pembrolizumab	Pembrolizumab	Phase 1 \& 2
Pegzilarginase plus Pembrolizumab	Pegzilarginase	Phase 1 \& 2

Primary Outcome Measures

Name	Time	Method
1. Phase 1: Incidence of treatment-related adverse events as assessed by CTCAE v4.0	Estimated up to 6 months	1. Number of participants experiencing treatment-related adverse events as assessed by CTCAE v4.0.
Phase 2: Efficacy determined by Objective Response Rate (ORR:CR+PR) per RECIST 1.1.	Estimated up to 6 months	1. Objective Response Rate (ORR:) per RECIST 1.1; • The Objective Response Rate (ORR) is defined as the percentage of subjects whose best objective response (BOR) is either complete response (CR) or partial response (PR). The ORR will be derived from the BOR according to response evaluation criteria in solid tumors (RECIST) v1.1 as assessed by the Investigator.

Secondary Outcome Measures

Name	Time	Method
Objective Response Rate	At 9, 18, and 27 weeks after first dose and every 12 weeks thereafter up to 24 months	Percentage of patients whose cancer achieves either complete response (CR) or partial response (PR).
Clinical Benefit Rate	At 18 and 27 weeks after first dose and every 12 weeks thereafter up to 24 months	Percentage of patients who have achieved CR, PR or Stable Disease (SD), lasting at least 8 weeks.
Time to Response	At 9, 18, and 27 weeks after first dose and every 12 weeks thereafter up to 24 months	Time (weeks) from first treatment to the first documented CR or PR.
Duration of Response	At 18 and 27 weeks after first dose and every 12 weeks thereafter up to 24 months	Time (weeks) from first documented CR or PR, until disease progression (PD).
Progression free survival	From first treatment up to 24 months	Time (weeks) from first treatment to first observation of PD or death from any cause.
Overall Survival	From first treatment up to 24 months	Time (weeks) from first treatment to death due to any cause.
Phase 2: Incidence of treatment-related adverse events as assessed by CTCAE v4.0	From first treatment up to 24 months	Number of participants experiencing treatment-related adverse events as assessed by CTCAE v4.0.

Trial Locations

Locations (22)

University of Alabama, Mitchell Cancer Institute; 🇺🇸 Mobile, Alabama, United States

Emory University; 🇺🇸 Atlanta, Georgia, United States

UPMC Cancer Center; 🇺🇸 Pittsburgh, Pennsylvania, United States

Texas Oncology-Memorial City; 🇺🇸 Houston, Texas, United States

Fundacion De Investigacion, Hematology/Oncology; 🇵🇷 San Juan, Puerto Rico

The Valley Hospital, Luckow Pavilion; 🇺🇸 Paramus, New Jersey, United States

Charleston Hematology Oncology Associates; 🇺🇸 Charleston, South Carolina, United States

West Clinic; 🇺🇸 Germantown, Tennessee, United States

Providence Cancer Center; 🇺🇸 Portland, Oregon, United States

Sarah Cannon Research Institute; 🇺🇸 Nashville, Tennessee, United States

Rocky Mountain Cancer Centers; 🇺🇸 Denver, Colorado, United States

Karmanos Cancer Institute; 🇺🇸 Detroit, Michigan, United States

University of Colorado; 🇺🇸 Aurora, Colorado, United States

Moffitt Cancer Center; 🇺🇸 Tampa, Florida, United States

Mid Florida Hematology and Oncology Centers; 🇺🇸 Orange City, Florida, United States

Woodlands Medical Specialists, PA; 🇺🇸 Pensacola, Florida, United States

University of Michigan; 🇺🇸 Ann Arbor, Michigan, United States

Nebraska Cancer Specialists; 🇺🇸 Omaha, Nebraska, United States

Washington University; 🇺🇸 Saint Louis, Missouri, United States

Oncology Hematology Care Inc.; 🇺🇸 Cincinnati, Ohio, United States

Oncology & Hematology Associates of SW Virginia; 🇺🇸 Blacksburg, Virginia, United States

Texas Oncology-Tyler; 🇺🇸 Tyler, Texas, United States