Association of Clinical Severity With Ultrasonographic, Electrophysiological, and Functional Parameters in Patients With Carpal Tunnel Syndrome: A Cross-Sectional Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 109
- 试验地点
- 2
- 主要终点
- Median Nerve Cross-Sectional Area Measured by Ultrasonography (mm²)
研究概览
简要总结
Carpal tunnel syndrome is one of the most common conditions caused by compression of a nerve at the wrist. It can lead to numbness, tingling, pain, weakness, and difficulty performing daily activities. Although nerve conduction studies are widely used to confirm the diagnosis and assess disease severity, ultrasonography has become an increasingly important, non-invasive diagnostic tool. However, the relationship between ultrasound findings, nerve conduction study results, hand function, and symptom severity has not been fully clarified.
The purpose of this study is to investigate the relationship between the clinical severity of carpal tunnel syndrome and ultrasonographic, electrophysiological, and functional parameters. Participants with carpal tunnel syndrome will undergo ultrasonographic measurement of the median nerve, nerve conduction studies, hand grip strength assessment, pressure pain threshold measurement, and completion of the Boston Carpal Tunnel Questionnaire.
The investigators hypothesize that greater clinical severity will be associated with larger median nerve cross-sectional area, more severe electrophysiological abnormalities, reduced hand grip strength, lower pressure pain threshold, and poorer functional status. The findings of this study may improve the understanding of the relationship between structural, electrophysiological, and functional changes in carpal tunnel syndrome and contribute to clinical evaluation and patient management.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults aged 18 years or older
- •Clinical findings consistent with carpal tunnel syndrome
- •Carpal tunnel syndrome confirmed by electroneuromyography
- •Ability to understand and complete the study assessments
- •Provision of written informed consent
排除标准
- •Previous carpal tunnel release surgery
- •History of fracture, major trauma, or surgery involving the assessed wrist or hand
- •Cervical radiculopathy, brachial plexopathy, or other peripheral neuropathy affecting the upper extremity
- •Polyneuropathy
- •Inflammatory rheumatic disease or active infection involving the assessed upper extremity
- •Severe neurological or musculoskeletal disorder that may affect hand function
- •Inability to complete ultrasonographic, electrophysiological, functional, or questionnaire assessments
研究组 & 干预措施
Mild Carpal Tunnel Syndrome
干预措施: Ultrasonographic and Clinical Assessment (Diagnostic Test)
Moderate Carpal Tunnel Syndrome
干预措施: Ultrasonographic and Clinical Assessment (Diagnostic Test)
Severe Carpal Tunnel Syndrome
干预措施: Ultrasonographic and Clinical Assessment (Diagnostic Test)
结局指标
主要结局
Median Nerve Cross-Sectional Area Measured by Ultrasonography (mm²)
时间窗: Baseline (prior to study assessments, during the single study visit)
The median nerve cross-sectional area will be measured by high-resolution ultrasonography at the carpal tunnel inlet (pisiform level). The mean of three measurements will be recorded in square millimeters (mm²).
次要结局
- Boston Carpal Tunnel Questionnaire Symptom Severity Score(Baseline (prior to study assessments, during the single study visit))
- Boston Carpal Tunnel Questionnaire Functional Status Score(Baseline (prior to study assessments, during the single study visit))
- Hand Grip Strength Measured Using a Jamar Dynamometer (kg)(Baseline (prior to study assessments, during the single study visit))
- Pressure Pain Threshold Measured Using a Digital Algometer (kPa)(Baseline (prior to study assessments, during the single study visit))
研究者
Hatice Zehra FERHATLAR
Principal Investigator
Kanuni Sultan Suleyman Training and Research Hospital