NCT05604573招募中不适用
DNA Mutation Detection in Circulating Tumor DNA and Tissue by Massive Multiplex Allele Discrimination Priming System(mmADPS) for Pancreatic Cancer
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- correlation of genetic mutation
研究概览
简要总结
Based on the cell free nucleic acid analysis information of blood samples and genetic mutation profile of EUS-FNB tissue from pancreatic cancer, the concordance between them is evaluated. And based on this information, biomarkers for diagnosis, treatment, and prognosis of pancreatic cancer are explored.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients diagnosed with pancreatic cancer through histological or radiologic examination and before treatment begins
- •Patients aged 18 or older who voluntarily agrees to participate in the study and is willing to understand and comply with the subsequent treatment procedures and sample collection schedule
- •Among patients diagnosed with benign pancreatic diseases (pancreatic cyst, chronic pancreatitis, etc.), patients who have need for histological examination as control group
排除标准
- •Where the subject himself/herself refuses to fill out the consent form or is unable to fill out the consent form
- •If a laboratory test is impossible due to a qualitative problem with the collected blood sample
- •Where the collected tissue does not contain tissue of the desired malignant or benign disease
结局指标
主要结局
correlation of genetic mutation
时间窗: the day of study enrollment (baseline)
concordance of genetic mutation between tissue and blood of treatment-naive status
detection sensitivity of genetic mutation by mmADPS
时间窗: the day of study enrollment (baseline)
detection sensitivity of genetic mutation by mmADPS
次要结局
- correlation of genetic mutation and prognosis(through study completion, an average of 1 year)
研究者
Sang Hyub Lee
Professor
Seoul National University Hospital
研究点 (1)
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