Predictive Factors for a Positive Exercise Bronchial Hyperresponsiveness Test
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Presence of wheezing at exercise
研究概览
简要总结
Exertional dyspnea has a significant impact on a child's daily life. Current guidelines recommend performing an exercise challenge test to confirm or rule out exercise-induced bronchoconstriction (EIB). But the test is not widely available. The objective of this research is to identify the clinical and respiratory functional factors predictive of a positive exercise challenge test in children.
详细描述
Exertional dyspnea is a frequent reason for consultation in pediatric pulmonology. The perception of dyspnea varies from one child to another, with some children over- or under- perceiving its intensity. Dyspnea has a significant impact on a child's daily life and quality of life and, in pediatrics, always raises the suspicion of exercise-induced asthma. Current guidelines recommend performing an exercise challenge test to confirm or rule out exercise-induced bronchoconstriction (EIB) if it is suspected. However, this test is not widely available. The objective of this research is to identify the clinical and respiratory functional factors predictive of a positive exercise challenge test in children.
The potential benefit of this study is to better identify individuals who would benefit from undergoing an exercise challenge test.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 5 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Children aged 5 to 18 years who performed an exercise challenge test during the years 2024 and 2025
排除标准
- •Children with doctor-diagnosed asthma
研究组 & 干预措施
Children with exercise-induced bronchocontriction
Children with a reduction in FEV1 ≥ 10% from baseline after the exercise challenge test
Children without exercise-induced bronchocontriction
Children with a reduction in FEV1 < 10% from baseline after the exercise challenge test
结局指标
主要结局
Presence of wheezing at exercise
时间窗: The test duration (3 hours)
Presence of reported exercise-induced wheezing, as documented in the subject's electronic medical record (yes/no; binary variable).
次要结局
- Presence of reported dyspnea at exercise(The test duration 3 hours)
- Presence of reported cough at exercise(The test duration 3 hours)
- Presence of reported chest tightness at exercise(The test duration 3 hours)
- Functional parameters - FEV1 z-score at baseline(The test duration 3 hours)
- Reported atopy(The test duration 3 hours)
- Reported clinical history(The test duration 3 hours)
- Functional parameters - FEV1/FVC z-score at baseline(The test duration 3 hours)
研究者
Dr. Iulia IOAN
Associate Professor MD PhD
Central Hospital, Nancy, France