Efficacy and Adverse Effects of Prapchompoothaweep Remedy and Loratadine for Treatment in AR Patients

Phase 2

Completed

• Conditions: Allergic Rhinitis; Loratadine, Prapchompoothaweep, Allergic rhinitis

• Registration Number: TCTR20181220002
• Lead Sponsor: Agricultural Research Development Agency

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2018-01-04
• Study Start: 2018-12-20
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 72

Inclusion Criteria

1. Aged between 18-70 years old.
2. Patients with history of allergic rhinitis based on ARIA guidelines. (itching and nasal obstruction, watery nasal discharge, sneezing ,congestion)
3. Patients with moderate allergic rhinitis was diagnosed by physicians.
4. Have no nasal septum perforation, nasal polyp or sinus surgery.
5. Have no serious medical conditions: Heart disease, Liver disease, Renal disease, Hypertension, Peptic Ulcer and Gastroesophageal reflux disease (GERD), severe Asthma, Tuberculosis.
6. Have normal range of Hematology test for Liver and Renal function.
7. No Pregnant or Lactation.
8. Do not taking a medicine constantly.
9. Volunteers are willing to participate this study.

Exclusion Criteria

1. Allergic reactions to Prapchompoothaweep remedy and Loratadine.
2. Allergic reaction to dairy products.
3. Have severe urticaria and anaphylaxis.
4. Have a serious condition of immunodeficiency disease: HIV in the previous month before being recruited in the study.
5. Participate in another study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
asal cavity Change from baseline at 6 weeks week-0, week-3 and week-6 Using an Acoustic Rhinometry to evaluate nasal symptoms,Nasal symptoms Change from baseline at 6 weeks. week-0, week-3 and week-6 Using Total Nasal Symptom Score Questionnaire.

Secondary Outcome Measures

Name	Time	Method
Assessment of well-being of volunteer that change from baseline at 6 weeks. week-0, week-3 and week-6 Using Rhinoconjunctivitis Questionnaire of Life (Thai Version copyright by Chaweewan Bunnag MD)