Plasma and synovial fluid pharmacokinetics of cefuroxime and linezolid in patients undergoing elective knee arthroscopy after a single intravenous dose of cefuroxime and linezolid: an exploratory microdialysis study - microdialysis knee study

Medizinische Universität Wien, Universitätsklinik für Klinische Pharmakologie0 个研究点开始时间: 2012年3月21日最近更新: 2013年7月15日

适应症

试验速览

暂无简介。

•Female or male, aged >18 years.
•Elective knee arthroscopy.
•Written informed consent.
•Therapeutic regimens will be not affected by procedures of the present study. The concomitant antimicrobial therapy with antibiotics other than linezolid and cefuroxime will be permitted throughout the study period.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 10
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•Allergy or hypersensitivity against study drugs.
•Treatment with cefuroxime or linezolid within the last week prior to the start of the study
•Treatment with another investigational drug within 1 month prior to start of study medication
•Any medication considered relevant for proper performance of the study, or risks to the patient, at the discretion of the investigator
•Impaired renal function (creatinine >1.5 mg/dl).
•Impaired liver function.
•Patients testing positive for HIV at the screening visit.
•Pregnancy or lactation.
•Hemodialysis or hemofiltration.
•Any disease considered relevant for proper performance of the study, or risks to the patient, at the discretion of the investigator
•No written informed consent

发起方

Medizinische Universität Wien, Universitätsklinik für Klinische Pharmakologie