ormal Range and Test/Re-Test Variability of Visual Acuity under different conditions of Contrast and Ambient Luminance (Tuebingen VA-CAL Test) in study participants with and without hereditary photoaversio

• Conditions: H53.5; H25; Colour vision deficiencies; H35; Senile cataract; Other retinal disorders

• Registration Number: DRKS00028003
• Lead Sponsor: niversitätsklinikum Tübingen, Department für Augenheilkunde

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-07-19
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 159

Inclusion Criteria

Control subjects:
BCVA monocular ? 0.8 decimal (Snellen 6/7.5); age 6 - 58 years; no history of abnormal glare sensitivity, no suspected or confirmed eye disease in history and/or standard eye examination; agreement to participate in the study.
Patients:
• Group 1: Achromatopsia (ACHM)
Age 6 - 58 years, VA ? 0.1 decimal, LOCSIII Cataract grading < 2 or pseudophacic
• Group 2: Cone dystrophy (CD)
Age 18 - 58 years, VA ? 0.1 decimal, LOCSIII Cataract grading < 2 or pseudophacic
• Group 3: Cataract (Cat)
Age 18 - 58 years, VA ? 0.2 decimal, history of increased subjective glare sensitivity (Note: as prevalence of cataract with glare sensitivity below age 58 is very rare, age limit may need to be expanded to age 80 years for cataract patients and comparison of Visual Acuity Space is then made not with values of controls but only with the average standard BCVA value of these individuals)
All groups: Agreement to participate in the study.

Exclusion Criteria

Control subjects: Subjects who are incapable of giving consent. Subjects with conspicuous OCT results.
Impaired vision group (Patients): Patients who are incapable of giving consent; having any eye disease other than achromatopsia, cone dystrophy, or cataract. Patients with conspicuous OCT results other than to be expected.
All groups: Any (additional) eye disease or systemic disease or condition having influence upon the measurement according to the judgement of the investigator and study physician.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Definition of the amount of change of visual acuity in 18 regions (A-R) and six zones of contrast and ambient luminance (A-D; E-H; I-L; M-P; Q, R) typical for activities of daily living (Visual Acuity Space (VAS); see Fig.1) and determination of normative values, sub-stratified by Age-correlated normative data (three age ranges) and/or gender. Furthermore, definition of test-retest variability in healthy subjects and ACHM patients.