A Study to Verify the Clinical Benefit of Aducanumab in Participants With Early Alzheimer's Disease
- Registration Number
- NCT05310071
- Lead Sponsor
- Biogen
- Brief Summary
The primary objective of this study is to verify the clinical benefit of monthly doses of aducanumab in slowing cognitive and functional impairment as measured by changes in the Clinical Dementia Rating Scale Sum of Boxes (CDR-SB) score as compared with placebo in participants with early Alzheimer's disease.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 1512
-
The participant must have confirmed amyloid beta pathology by cerebrospinal fluid (CSF) or amyloid PET
-
Must have a history of subjective memory decline with gradual onset and slow progression over the 6 months before Screening, confirmed by study partner
-
The participant must have 1 informant/care partner who, in the Investigator's opinion, has frequent and sufficient contact with the participant (at least 10 hours/week in person or by phone) as to be able to provide accurate information about the participant's cognitive and functional abilities over time
-
Must meet all of the following clinical criteria for MCI due to Alzheimer's disease or mild Alzheimer's disease according to National Institute on Aging and Alzheimer's Association (NIA-AA) criteria
- Have an MMSE score between 22 and 30 inclusive
- Have a CDR memory score >0.5
- Have a Clinical Dementia Rating Scale Global Score (CDR-GS) of 0.5 or 1.0
- Have a Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) score of 85 or lower indicative of objective cognitive impairment
-
Apart from a clinical diagnosis of early Alzheimer's disease, the participant must be in good health as determined by the Investigator based on medical history and screening assessments
-
Must consent to apolipoprotein E (ApoE) genotyping. (Note: Participants are not required to be ApoE ε4 carriers)
Key
- Any uncontrolled medical or neurological/neurodegenerative condition (other than Alzheimer's disease) that, in the opinion of the Investigator, might be a contributing cause of the participant's cognitive impairment
- Clinically significant and/or unstable psychiatric illness within 6 months prior to Screening
- Transient ischemic attack or stroke or any unexplained loss of consciousness within 1 year prior to Screening
- History of severe allergic or anaphylactic reactions or of hypersensitivity to any of the inactive ingredients in the drug product
- Participation in any study with purported disease-modifying effect in Alzheimer's disease within 12 months prior to Screening unless documentation of receipt of placebo is available
- Current use or previous use of medications with a purported disease-modifying effect in Alzheimer's disease, outside of investigational studies
- Use of any medications that, in the opinion of the Investigator, may contribute to cognitive impairment, put the participant at higher risk for AEs, or impair the participant's ability to perform cognitive testing or complete study procedures
- Use of any investigational drug
- Prior exposure to aducanumab either commercially or by participation in a previous study with aducanumab. (Participants are eligible if they did not receive active aducanumab.)
- A negative PET scan result with any amyloid-targeting ligand within 12 months prior to Screening
NOTE: Other protocol defined Inclusion/Exclusion criteria may apply
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Aducanumab Aducanumab Participants will receive aducanumab, up to 10 milligrams per kilogram (mg/kg), monthly (once every four weeks), administered as intravenous (IV) infusion. Placebo Placebo Participants will receive placebo, monthly (once every four weeks), administered as IV infusion.
- Primary Outcome Measures
Name Time Method Change From Baseline in Clinical Dementia Rating Scale - Sum of Boxes (CDR-SB) Score at Week 78 Baseline, Week 78 The Clinical Dementia Rate Scale integrates assessments from 3 domains of cognition (memory, orientation, judgment/problem-solving) and 3 domains of function (community affairs, home/hobbies, personal care). Following the caregiver interview and systematic participant examination, the rater assigns a score describing the participant's current performance level in each of these domains of life functioning. The "Sum of boxes" scoring methodology sums the score for each of the 6 domains and provides a value ranging from 0 to 18. Higher scores indicate greater impairment. A positive change from baseline indicates greater impairment.
- Secondary Outcome Measures
Name Time Method Change From Baseline in Integrated Alzheimer's Disease Rating Scale (iADRS) Score at Weeks 78 and 106 Baseline, Weeks 78 and 106 The iADRS composite captures a decline in both cognition and daily function. It is a simple linear combination of the Alzheimer's disease assessment scale, cognitive subscale (ADAS-Cog13), and the Alzheimer's disease cooperative study scale for activities of daily living in mild cognitive impairment (ADCS-ADL-MCI). The ADAS-Cog13 scale ranges from 0 to 85 (higher scores indicate worse performance) and the ADCS-ADL-MCI scale ranges from 0 to 53 (higher scores indicate greater independent, healthy functioning). The total score for iADRS scale ranges from 0 to 138, where higher scores indicate better performance.
Change From Baseline in Alzheimer's Disease Cooperative Study for Activities of Daily Living in Mild Cognitive Impairment (ADCS-ADL-MCI) Scale Score at Weeks 78 and 106 Baseline, Weeks 78 and 106 The ADCS-ADL-MCI scale consists of 17 instrumental items (e.g., shopping, preparing meals, using household appliances, etc) and 1 basic item (getting dressed). Ratings reflect caregiver observations about the participant's actual functioning over the previous month and provide an assessment of change in the functional state of the participant over time. The total score ranges from 0 to 53. Higher scores indicate greater independent, healthy functioning. A positive change from baseline indicates healthy functioning while a negative change from baseline indicates a decline in independent functioning.
Change From Baseline in Alzheimer's Disease Assessment Scale, Cognitive Subscale (ADAS-Cog13) at Weeks 78 and 106 Baseline, Weeks 78 and 106 ADAS-Cog13 comprises both cognitive tasks and clinical ratings of cognitive performance. The cognitive subscale items capture word recall, ability to follow commands, the ability to correctly copy or draw an image, naming, the ability to interact with everyday objects, orientation, word recognition, memory, comprehension of spoken language, word-finding, and language ability, with a measure for delayed word recall and concentration/distractibility. The total score ranges from 0 to 85. Higher scores indicate worse performance. A positive change from baseline indicates decline in cognitive performance.
Change From Baseline in Mini-Mental State Examination (MMSE) Scale Score at Weeks 78 and 106 Baseline, Weeks 78 and 106 The MMSE scale is a performance-based test of global cognitive status. It consists of 11 tasks that assess orientation, word recall, attention and calculation, language abilities, and visuospatial functions. The scores from the 11 tests are combined to obtain the total score, which ranges from 0 to 30. Higher scores indicate better performance. A negative change from baseline indicates decline in cognitive performance.
Change From Baseline in Neuropsychiatric Inventory-10 (NPI-10) Score at Weeks 78 and 106 Baseline, Weeks 78 and 106 The NPI-10 is a questionnaire administered to the informant, designed to obtain information on the presence of neuropsychiatric symptoms and behaviors in a participant with Alzheimer's disease. Ten areas are assessed: delusions, hallucinations, agitation/aggression, depression, anxiety, elation/euphoria, apathy/indifference, disinhibition, irritability and aberrant motor behavior. The NPI total score ranges from 0 to 120. Higher scores indicate greater impairment. A negative change from baseline indicates improvement (symptom reduction).
Change From Baseline in Amyloid Positron Emission Tomography (PET) Signal at Weeks 78 and 104 Baseline, Weeks 78 and 104 Amyloid PET scan assesses cerebral amyloid load using radiotracers which is standardized into centiloids. Centiloid values on centiloid scale is based on mean composite standardized uptake value ratio (SUVR).
Change From Baseline in Tau PET Signal at Weeks 78 and 104 Baseline, Weeks 78 and 104 The cerebral tau level was measured by tau PET imaging. Tau PET imaging was conducted using radiotracer. SUVR is a ratio of PET uptake measured in brain region of interest and a disease-free reference region. A higher SUVR is an indication of increased PET radiotracer uptake and worsening disease.
Change From Baseline in CDR-SB Score at Week 106 Baseline, Week 106 The CDR integrates assessments from 3 domains of cognition (memory, orientation, judgment/problem-solving) and 3 domains of function (community affairs, home/hobbies, personal care). Following caregiver interview and systematic participant examination, the rater assigns a score describing the participant's current performance level in each of these domains of life functioning. The CDR-SB sums the score for each of the 6 domains and provides a value ranging from 0 to 18. Higher scores indicate greater impairment. Positive change from baseline indicates greater impairment.
Change From Baseline in Global Statistical Test (GST) Composite Z-Score at Weeks 78 and 106 Baseline, Weeks 78 and 106 GST z-score is an average of z-scores of CDR-SB, ADASCog13 and ADCS-ADL-MCI. CDR-SB assesses 3 cognitive (memory,orientation, judgment/problem-solving)and 3 functional(community affairs,home/hobbies,personal care) domains. Sum of Boxes method combines scores across 6 domains, ranging from 0-18(higher scores=greater impairment). ADAS-Cog13 evaluates cognitive tasks like word recall, naming, orientation and memory, with scores from 0-85 (higher scores=worse performance). ADCS-ADL-MCI rates 17 tasks (e.g.,shopping, preparing meal) and 1 basic task(dressing) with scores from 0-53 (higher scores=greater independence/healthy functioning). z-score\>0 indicates greater impairment/worse performance for CDR-SB and ADASCog13 scales and improved functioning for ADCS-ADL-MCI. For ADCS-ADL-MCI, z-score were reversed (new reversed value=original value-1) to make interpretation consistent. The GST z-score of 0 indicates population mean and score\>0 indicate greater impairment/worse performance.
Trial Locations
- Locations (262)
K2 Medical Research
🇺🇸Orlando, Florida, United States
Headlands Research LLC
🇺🇸Orlando, Florida, United States
Conquest Research
🇺🇸Orlando, Florida, United States
Central States Research, LLC
🇺🇸Tulsa, Oklahoma, United States
Clinical Trial Network LLC
🇺🇸Houston, Texas, United States
Central Texas Neurology Consultants
🇺🇸Round Rock, Texas, United States
University of Texas Health Science Center at San Antonio
🇺🇸San Antonio, Texas, United States
The Memory Clinic
🇺🇸Bennington, Vermont, United States
UBC Hospital
🇨🇦Vancouver, British Columbia, Canada
Centricity Research Halifax
🇨🇦Halifax, Nova Scotia, Canada
Recherches Neuro-Hippocampe Inc., d/b/a Ottawa Memory Clinic
🇨🇦Ottawa, Ontario, Canada
Kawartha Centre - Redefining Healthy Aging
🇨🇦Peterborough, Ontario, Canada
Toronto Memory Program (Neurology Research Inc.)
🇨🇦Toronto, Ontario, Canada
Centricity Research Toronto LMC
🇨🇦Toronto, Ontario, Canada
Gilbert Neurology Partners, PLLC
🇺🇸Gilbert, Arizona, United States
Xenoscience Inc.
🇺🇸Phoenix, Arizona, United States
Banner Alzheimer's Institute
🇺🇸Tucson, Arizona, United States
Barrow Neurological Institute
🇺🇸Phoenix, Arizona, United States
HonorHealth Neurology
🇺🇸Scottsdale, Arizona, United States
Mayo Clinic Arizona
🇺🇸Scottsdale, Arizona, United States
Banner Sun Health Research Institute
🇺🇸Sun City, Arizona, United States
Infinity Clinical Research, LLC
🇺🇸Hollywood, Florida, United States
Charter Research, LLC
🇺🇸Lady Lake, Florida, United States
ARS - Lake Oconee
🇺🇸Lakeland, Florida, United States
Medical Research Center
🇺🇸Miami, Florida, United States
Renstar Medical Research
🇺🇸Ocala, Florida, United States
K2 Medical Research, LLC
🇺🇸Orlando, Florida, United States
Nova Clinical Research, LLC
🇺🇸Bradenton, Florida, United States
JY Research Institute
🇺🇸Cutler Bay, Florida, United States
Brain Matters Research
🇺🇸Stuart, Florida, United States
Neurology Offices of South Florida, PLLC
🇺🇸Boca Raton, Florida, United States
ECommunity Research, LLC
🇺🇸Boca Raton, Florida, United States
The Neuron Clinic
🇺🇸San Marcos, California, United States
Syrentis Clinical Research
🇺🇸Santa Ana, California, United States
California Neuroscience Research, LLC
🇺🇸Sherman Oaks, California, United States
Inage Neurology and Memory Clinic
🇯🇵Chiba-shi, Chiba-Ken, Japan
Viking Clinical Research Center
🇺🇸Temecula, California, United States
Hakuyokai Kashiwado Hospital
🇯🇵Chiba-shi, Chiba-Ken, Japan
Health Initiatives Research
🇺🇸Fayetteville, Arkansas, United States
Sun Valley Behaivoral Med Center
🇺🇸El Centro, California, United States
Neuropain Medical Center
🇺🇸Fresno, California, United States
Neurology Center of North Orange County
🇺🇸Fullerton, California, United States
Irvine Center for Clinical Research, Inc.
🇺🇸Irvine, California, United States
Mary S. Easton Center for Alzheimer's Disease Research, UCLA
🇺🇸Los Angeles, California, United States
Hoag Memorial Hospital Presbyterian
🇺🇸Newport Beach, California, United States
Stanford Hospital and Clinics
🇺🇸Palo Alto, California, United States
VA Palo Alto Health Care System
🇺🇸Palo Alto, California, United States
Anderson Clinical Research
🇺🇸Redlands, California, United States
Sutter Health-San Francisco
🇺🇸San Francisco, California, United States
University of California San Francisco (PARENT)
🇺🇸San Francisco, California, United States
University of Colorado Anschutz Medical Campus
🇺🇸Aurora, Colorado, United States
Mountain Neurological Research Center
🇺🇸Basalt, Colorado, United States
Yale University
🇺🇸Fairfield, Connecticut, United States
Institute for Neurodegenerative Disorders (IND)
🇺🇸New Haven, Connecticut, United States
Yale University School Of Medicine
🇺🇸New Haven, Connecticut, United States
Research Center for Clinical Studies, Inc.
🇺🇸Norwalk, Connecticut, United States
Howard University Health Sciences
🇺🇸Washington, District of Columbia, United States
Neurology of Central Florida Research Center, LLC
🇺🇸Altamonte Springs, Florida, United States
JEM Research Institute
🇺🇸Atlantis, Florida, United States
Neuropsychiatric Research Center of Southwest Florida
🇺🇸Fort Myers, Florida, United States
Quantum Laboratories Inc.
🇺🇸Pompano Beach, Florida, United States
United Medical Research
🇺🇸Port Orange, Florida, United States
K2 Medical Research Tampa
🇺🇸Tampa, Florida, United States
USF Health Byrd Institute
🇺🇸Tampa, Florida, United States
Hawaii Pacific Neuroscience
🇺🇸Honolulu, Hawaii, United States
Great Lakes Clinical Trials, LLC Ravenswood dba Flourish Research
🇺🇸Chicago, Illinois, United States
University of Chicago Medical Center
🇺🇸Chicago, Illinois, United States
Alexian Brothers Medical Center - Neuroscience Research Institute
🇺🇸Elk Grove Village, Illinois, United States
Indiana University School of Medicine
🇺🇸Indianapolis, Indiana, United States
University of Kansas Medical Center Research Institute, Inc.
🇺🇸Fairway, Kansas, United States
Ascension Via Christi Research, a division of Ascension Via Christi Hospitals Wichita, Inc.
🇺🇸Wichita, Kansas, United States
University of Kentucky Medical Center
🇺🇸Lexington, Kentucky, United States
Ochsner Health System PARENT
🇺🇸New Orleans, Louisiana, United States
LSU Health Sciences Center Shreveport
🇺🇸Shreveport, Louisiana, United States
University of Maryland Medical Center
🇺🇸Baltimore, Maryland, United States
McLean Hospital
🇺🇸Belmont, Massachusetts, United States
Brigham and Women's Hospital Department of Neurology
🇺🇸Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center
🇺🇸Boston, Massachusetts, United States
ActivMed Practices and Research
🇺🇸Methuen, Massachusetts, United States
Boston Center for Memory
🇺🇸Newton, Massachusetts, United States
Donald S. Marks, M.D., P.C.
🇺🇸Plymouth, Massachusetts, United States
Wayne State University - Detroit Medical Center
🇺🇸Detroit, Michigan, United States
Michigan Institute for Neurological Disorders
🇺🇸Farmington Hills, Michigan, United States
Center for Memory and Aging
🇺🇸Saint Paul, Minnesota, United States
Hattiesburg Clinic, PA
🇺🇸Hattiesburg, Mississippi, United States
Sharlin Health and Neurology
🇺🇸Ozark, Missouri, United States
University of Nebraska Medical Center
🇺🇸Omaha, Nebraska, United States
Cleveland Clinic Lou Ruvo Center for Brain Health
🇺🇸Las Vegas, Nevada, United States
Las Vegas Medical Research
🇺🇸Las Vegas, Nevada, United States
The Cognitive Research Center of New Jersey
🇺🇸Springfield, New Jersey, United States
CenExel Advanced Memory Research Institute of NJ
🇺🇸Toms River, New Jersey, United States
Neurological Associates of Albany, PC
🇺🇸Albany, New York, United States
Dent Neurologic Institute
🇺🇸Amherst, New York, United States
Social Psychiatry Research Institute (SPRI)
🇺🇸Brooklyn, New York, United States
New York University Medical Center PRIME
🇺🇸New York, New York, United States
Mount Sinai
🇺🇸New York, New York, United States
South Shore Neurologic Associates, P.C.
🇺🇸Patchogue, New York, United States
Finger Lakes Clinical Research
🇺🇸Rochester, New York, United States
University of Rochester - PARENT
🇺🇸Rochester, New York, United States
Richmond Behavioral Associates ERG Clinical Research - New York PLLC
🇺🇸Staten Island, New York, United States
Stony Brook University Hospital
🇺🇸Stony Brook, New York, United States
SUNY Upstate Medical University
🇺🇸Syracuse, New York, United States
IMA Evaluations LLC
🇺🇸Tarrytown, New York, United States
Duke University
🇺🇸Durham, North Carolina, United States
AMC Research, LLC
🇺🇸Matthews, North Carolina, United States
Wake Forest Baptist Health Sciences
🇺🇸Winston-Salem, North Carolina, United States
Cleveland Clinic Foundation
🇺🇸Cleveland, Ohio, United States
Ohio State University Medical Center
🇺🇸Columbus, Ohio, United States
Neuro-Behavioral Clinical Research, Inc.
🇺🇸North Canton, Ohio, United States
Lynn Health Science Institute
🇺🇸Oklahoma City, Oklahoma, United States
Oregon Health & Science University (OHSU)
🇺🇸Portland, Oregon, United States
Abington Neurological Associates, LTD
🇺🇸Abington, Pennsylvania, United States
The Clinical Trial Center, LLC
🇺🇸Jenkintown, Pennsylvania, United States
Penn Memory Center
🇺🇸Philadelphia, Pennsylvania, United States
Rhode Island Hospital
🇺🇸East Providence, Rhode Island, United States
Rhode Island Mood & Memory Research Institute
🇺🇸East Providence, Rhode Island, United States
Butler Hospital
🇺🇸Providence, Rhode Island, United States
Coastal Neurology PA
🇺🇸Port Royal, South Carolina, United States
Neurology Clinic, PC
🇺🇸Cordova, Tennessee, United States
Genesis Neuroscience Clinic
🇺🇸Knoxville, Tennessee, United States
Senior Adult Specialty Research
🇺🇸Austin, Texas, United States
Headlands Research - Brownsville
🇺🇸Brownsville, Texas, United States
Kerwin Medical Center
🇺🇸Dallas, Texas, United States
UT Southwestern Medical Center
🇺🇸Dallas, Texas, United States
University of North Texas Health Science Center
🇺🇸Fort Worth, Texas, United States
Baylor College Of Medicine
🇺🇸Houston, Texas, United States
The Methodist Hospital Research Institute
🇺🇸Houston, Texas, United States
University of Virginia Health System
🇺🇸Charlottesville, Virginia, United States
Glennan Center for Geriatrics and Gerontology
🇺🇸Norfolk, Virginia, United States
National Clinical Research Inc. - Richmond
🇺🇸Richmond, Virginia, United States
University of Washington Medical Center
🇺🇸Seattle, Washington, United States
Kingfisher Cooperative, LLC
🇺🇸Spokane, Washington, United States
University of Wisconsin-Madison
🇺🇸Madison, Wisconsin, United States
Marshfield Clinic
🇺🇸Marshfield, Wisconsin, United States
Medical College of Wisconsin, Inc.
🇺🇸Milwaukee, Wisconsin, United States
St Vincent's Hospital Sydney
🇦🇺Darlinghurst, New South Wales, Australia
KaRa Institute of Neurological Diseases
🇦🇺Macquarie Park, New South Wales, Australia
Box Hill Hospital
🇦🇺Box Hill, Victoria, Australia
Frankston Hospital
🇦🇺Frankston, Victoria, Australia
Austin Health
🇦🇺Heidelberg, Victoria, Australia
The Alfred Hospital
🇦🇺Melbourne, Victoria, Australia
Royal Melbourne Hospital
🇦🇺Parkville, Victoria, Australia
Australian Alzheimer's Research Foundation
🇦🇺Nedlands, Western Australia, Australia
UZ Leuven
🇧🇪Leuven, Flemish Brabant, Belgium
AZ Sint-Jan
🇧🇪Brugge, Belgium
Universitair Ziekenhuis Brussel
🇧🇪Brussel, Belgium
AZ Groeninge
🇧🇪Kortrijk, Belgium
Trial Tech Tecnologia em Pesquisas com Medicamentos Ltda
🇧🇷Curitiba, Paraná, Brazil
Instituto de Neurologia de Curitiba - Hospital Ecoville
🇧🇷Curitiba, Paraná, Brazil
IMV Pesquisa Neurologica Sociedade Simples Ltda
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Instituto do Cerebro do Rio Grande do Sul
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
IPq-HCFMUSP - Instituto de Psiquiatria do Hospital das Clínicas da FMUSP
🇧🇷São Paulo, Sao Paulo, Brazil
University of Calgary - Heritage Medical Research Clinic
🇨🇦Calgary, Alberta, Canada
Sunnybrook Health Sciences Centre
🇨🇦Toronto, Ontario, Canada
Toronto Western Hospital
🇨🇦Toronto, Ontario, Canada
Baycrest Centre for Geriatric Care
🇨🇦Toronto, Ontario, Canada
Clinique de la Memoire de l'Outaouais
🇨🇦Gatineau, Quebec, Canada
MoCA Research and Innovation Inc
🇨🇦Greenfield-Park, Quebec, Canada
Montreal Neurological Institute Clinical Research Unit
🇨🇦Montréal, Quebec, Canada
CHU de Quebec- Hopital de l Enfant Jesus
🇨🇦Quebec, Canada
Terveystalo Ruoholahti
🇫🇮Helsinki, Finland
CRST, Clinical Research Services Turku
🇫🇮Turku, Finland
CHU Strasbourg - Hôpital Hautepierre
🇫🇷Strasbourg Cedex, Bas Rhin, France
Hôpital de la Timone
🇫🇷Marseille cedex 05, Bouches-du-Rhône, France
Groupe Hospitalier Pellegrin - Hôpital Pellegrin
🇫🇷Bordeaux Cedex, Gironde, France
Hôpital La Grave
🇫🇷Toulouse Cedex 9, Haute Garonne, France
Hopital Gui de Chauliac
🇫🇷Montpellier, Herault, France
CHU Rennes - Pontchaillou
🇫🇷Rennes cedex 9, Ille Et Vilaine, France
CHU Nantes - Hopital Nord Laënnec
🇫🇷Saint-Herblain, Loire Atlantique, France
Hopital Roger Salengro - CHU Lille
🇫🇷Lille Cedex, Nord, France
Hôpital Lariboisière
🇫🇷Paris cedex 10, Paris, France
Hôpital des Chapennes
🇫🇷Villeurbanne, Rhone, France
Groupe Hospitalier Pitie-Salpetriere
🇫🇷Paris, France
Hôpital Broca
🇫🇷Paris, France
Universitaetsklinikum Freiburg
🇩🇪Freiburg, Baden Wuerttemberg, Germany
ISPG - Institut fuer Studien zur Psychischen Gesundheit
🇩🇪Mannheim, Baden Wuerttemberg, Germany
Universitaetsklinikum Tuebingen
🇩🇪Tuebingen, Baden Wuerttemberg, Germany
Klinikum Bayreuth GmbH- Hohe Warte
🇩🇪Bayreuth, Bayern, Germany
Institut fuer Schlaganfall- und Demenzforschung (ISD)
🇩🇪Muenchen, Bayern, Germany
Klinikum rechts der Isar der TU Muenchen
🇩🇪Muenchen, Bayern, Germany
Zentrum für klinische Forschung Dr.med. Irma Schöll
🇩🇪Bad Homburg, Hessen, Germany
Universitaetsklinikum Frankfurt Goethe-Universitaet
🇩🇪Frankfurt, Hessen, Germany
Universitaetsmedizin Greifswald
🇩🇪Greifswald, Mecklenburg Vorpommern, Germany
Universitaetsmedizin Goettingen
🇩🇪Goettingen, Niedersachsen, Germany
Katholisches Klinikum Bochum gGmbH
🇩🇪Bochum, Nordrhein Westfalen, Germany
Deutsches Zentrum fuer Neurodegenerative Erkrankungen (DZNE)
🇩🇪Bonn, Nordrhein Westfalen, Germany
Universitaetsklinikum Duesseldorf AoeR
🇩🇪Duesseldorf, Nordrhein Westfalen, Germany
Universitaetsklinikum Koeln
🇩🇪Koeln, Nordrhein Westfalen, Germany
Universitaetsklinikum Magdeburg
🇩🇪Magdeburg, Sachsen Anhalt, Germany
Universitaetsklinikum Carl Gustav Carus TU Dresden
🇩🇪Dresden, Sachsen, Germany
NEUROZENTRUM tempelhof.berlin
🇩🇪Berlin, Germany
Charité - Universitätsmedizin Berlin
🇩🇪Berlin, Germany
Azienda Ospedaliera Card. G. Panico
🇮🇹Tricase, Lecce, Italy
ASST di Monza
🇮🇹Monza, Milano, Italy
Fondazione Istituto G.Giglio di Cefalù
🇮🇹Cefalù, Palermo, Italy
Ospedale di Arzignano
🇮🇹Arzignano VI, Vicenza, Italy
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili)
🇮🇹Brescia, Italy
IRCCS Ospedale Policlinico San Martino
🇮🇹Genova, Italy
Ospedale San Raffaele
🇮🇹Milano, Italy
Azienda Ospedaliera Universitaria- Università degli Studi della Campania "Luigi Vanvitelli"
🇮🇹Napoli, Italy
Azienda Ospedaliera e Universitaria di Perugia
🇮🇹Perugia, Italy
Fondazione Santa Lucia IRCCS
🇮🇹Roma, Italy
Azienda Ospedaliera Universitaria Policlinico Umberto I - Università di Roma La Sapienza
🇮🇹Roma, Italy
Azienda Ospedaliera Universitaria OO. RR. S. Giovanni di Dio e Ruggi D'Aragona
🇮🇹Salerno, Italy
National Center For Geriatrics And Gerontology
🇯🇵Obu-shi, Aichi-Ken, Japan
Southern Tohoku Medical Clinic
🇯🇵Koriyama-shi, Fukushima-Ken, Japan
NHO Hiroshima-Nishi Medical Center
🇯🇵Otake-shi, Hiroshima-Ken, Japan
Himeji Central Hospital Clinic
🇯🇵Himeji-shi, Hyogo-Ken, Japan
Kagawa University Hospital
🇯🇵Kita-gun, Kagawa-Ken, Japan
Tokushukai Shonan Atsugi Hospital
🇯🇵Atsugi-shi, Kanagawa-Ken, Japan
Tokushukai Shonan Kamakura General Hospital
🇯🇵Kamakura-shi, Kanagawa-Ken, Japan
Teikyo University Hospital, Mizonokuchi
🇯🇵Kawasaki-shi, Kanagawa-Ken, Japan
Rakuwakai Otowa Rehabilitation Hospital
🇯🇵Kyoto-shi, Kyoto-Fu, Japan
NHO Utano National Hospital
🇯🇵Kyoto-shi, Kyoto-Fu, Japan
Katayama Medical Clinic
🇯🇵Kurashiki-shi, Okayama-Ken, Japan
Tokushukai Kishiwada Tokushukai Hospital
🇯🇵Kishiwada-shi, Osaka-Fu, Japan
Osaka University Hospital
🇯🇵Suita-shi, Osaka-Fu, Japan
Midorikai Takesato Hospital
🇯🇵Kasukabe-shi, Saitama-Ken, Japan
Memory Clinic Ochanomizu
🇯🇵Bunkyo-ku, Tokyo-To, Japan
National Center of Neurology and Psychiatry
🇯🇵Kodaira-shi, Tokyo-To, Japan
Tokushukai Yamagata Tokushukai Hospital
🇯🇵Yamagata-shi, Yamagata-Ken, Japan
Seoul National University Bundang Hospital
🇰🇷Seongnam, Gyeonggi-do, Korea, Republic of
Konkuk University Medical Center
🇰🇷Seoul, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Health Pharma Professional Research S.A. de C.V.
🇲🇽Ciudad de México, Distrito Federal, Mexico
Hospital Mexico Americano SC
🇲🇽Guadalara, Jalisco, Mexico
Hospital Universitario Dr. Jose Eleuterio Gonzalez
🇲🇽Monterrey, Nuevo León, Mexico
Centro de Estudios Clinicos y Especialidades Medicas, S.C.
🇲🇽Monterrey, Nuevo León, Mexico
AVIX Investigación Clínica S.C
🇲🇽Monterrey, Nuevo León, Mexico
PROMENTE Sp. z o.o.
🇵🇱Bydgoszcz, Kujawsko-Pomorskie Województwo, Poland
Centrum Medyczne NeuroProtect
🇵🇱Warszawa, Mazowieckie Województwo, Poland
Podlaskie Centrum Psychogeriatrii
🇵🇱Bialystok, Podkarpackie Wojewódctwo, Poland
Centrum Medyczne Senior
🇵🇱Sopot, Pomorskie Województwo, Poland
Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie Kliniczny Oddział Neurologii Oddział Udarowy
🇵🇱Lublin, Poland
NZOZ Wroclawskie Centrum Alzheimerowskie
🇵🇱Wroclaw, Poland
Nzoz Novo-Med
🇵🇱Katowice, Śląskie Województwo, Poland
Neuro-Care Gabriela Klodowska
🇵🇱Siemianowice Slaskie, Śląskie Województwo, Poland
Hospital Universitario Reina Sofia
🇪🇸Cordoba, Córdoba, Spain
Policlinica Gipuzkoa
🇪🇸San Sebastian, Guipuzcoa, Spain
Clinica Universidad de Navarra
🇪🇸Pamplona, Navarra, Spain
Fundacio ACE
🇪🇸Barcelona, Spain
Hospital Clinic de Barcelona
🇪🇸Barcelona, Spain
Hospital de la Santa Creu i Sant Pau
🇪🇸Barcelona, Spain
Hospital Universitari de Santa Maria
🇪🇸Lleida, Spain
Clinica Universidad de Navarra (MAD)
🇪🇸Madrid, Spain
Hospital Victoria Eugenia
🇪🇸Sevilla, Spain
Hospital Universitario Dr. Peset
🇪🇸Valencia, Spain
Hospital Universitari i Politecnic La Fe
🇪🇸Valencia, Spain
Skane University Hospital
🇸🇪Malmö, Scania, Sweden
Sahlgrenska Universitetssjukhuset, Mölndal Sjukhus
🇸🇪Mölndal, Västra Götaland, Sweden
Karolinska Universitetssjukhuset
🇸🇪Stockholm, Sweden
The University of Edinburgh
🇬🇧Edinburgh, East Lothian, United Kingdom
Institute of Psychiatry, Psychology and Neuroscience
🇬🇧London, Greater London, United Kingdom
Re:Cognition Health Ltd (London)
🇬🇧London, Greater London, United Kingdom
Charing Cross Hospital
🇬🇧London, Greater London, United Kingdom
Park House
🇬🇧Manchester, Greater Manchester, United Kingdom
Southampton General Hospital
🇬🇧Southampton, Hampshire, United Kingdom
Moorgreen Hospital
🇬🇧Southampton, Hampshire, United Kingdom
Brain Health Scotland Life Sciences
🇬🇧Edinburgh, Lothian Region, United Kingdom
The RICE Centre
🇬🇧Bath, Somerset, United Kingdom
Glasgow Memory Clinic Ltd
🇬🇧Motherwell, Strathclyde, United Kingdom
Re Cognition Health Bristol
🇬🇧Bristol, United Kingdom