Whether Controlling Serum Uric Acid (SUA) Can Benefit Postoperative Survival in Patients With Pancreatic Cancer
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 168
- 试验地点
- 1
- 主要终点
- Overall survival
研究概览
简要总结
This retrospective study aims to analyze the impact of postoperative changes in serum uric acid (SUA) levels on the prognosis of patients undergoing pancreatic cancer resection.
详细描述
Serum uric acid is a risk factor for gallbladder cancer in men and has a strong effect on pancreatic cancer in women. It has also been shown that elevated intracellular serum uric acid can induce an inflammatory stress response, which may promote its transformation, while elevated extracellular serum uric acidy further stimulate tumor cell proliferation, migration, and survival, and promote the development of highly aggressive cancer. In this study, the changes of serum uric acid before and after surgery was used as a prognostic marker for the survival of pancreatic cancer patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with pathologically confirmed pancreatic cancer (primary)
- •Patients who underwent Radical resection of pancreatic cancer（Pancreaticoduodenectomy or Distal pancreatectomy）
- •The postoperative survival time was at least 6 weeks
排除标准
- •No surgery was performed, or only palliative surgery/ biopsy was performed
- •Patients who underwent emergency hemodialysis or plasma exchange after surgery
- •History of gout or long-term urate-lowering therapy, such as allopurinol
- •Patients are missing follow-up data
- •Hydrochlorothiazide and furosemide were used
- •Chronic kidney disease
- •Oncolytic syndrome
- •Hemolytic anemia
- •Lead poisoning
- •Hyperparathyroidism
- •Hypothyroidism
- •A tyrosinase inhibitor was used
- •Patients with nonpancreatic primary tumors
- •Pregnant or postpartum women.
结局指标
主要结局
Overall survival
时间窗: 3-5 years
Overall survival was defined as the time from diagnosis to death.
次要结局
- Biliary fistula(3 months)
- Abdominal cavity infection(3 months)
- Cost of hospitalization(3 months)
- Pancreatic fistula(3 months)
- Recurrence-free survival(3-5 years)
- Bleeding(3 months)
- Length of hospital stay(3 months)
研究者
Wenbo Meng
Director of Surgery
Hepatopancreatobiliary Surgery Institute of Gansu Province