Effect of two different combination drug therapies on control of joints inflammation in rheumatoid arthritis
Not Applicable
- Conditions
- ESR normalization and remission in response to treatment in rheumatoid arthritis.Rheumatoid arthritis, unspecified
- Registration Number
- IRCT2012110611383N1
- Lead Sponsor
- Rheumatology Department, Valiasr Hospital, Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 52
Inclusion Criteria
the age of 18 and over; fulfilling the the American College of Rheumatology criteria 1987 for rheumatoid arthritis; active disease which specified by ESR equal to or more than 20 in males and equal to or more than 30 in females; morning stiffness more than 30 minutes and equal to or more than 3 joints involved in physical exam.
Exclusion criteria: stage IV disease; previous combination therapy with the same medication as in this study; liver or renal failure; pregnancy; active or chronic infection; anemia; ophthalmic complications of Chloroquine during follow up; patients with irregular visits; the patients without drug compliance and special medical complications such as rise of serum creatinine.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ESR normalization (time to normalize ESR and percentage of normalization). Timepoint: 2nd, 4th, 6th, 8th, 18th, 34th week. Method of measurement: westergren method.
- Secondary Outcome Measures
Name Time Method Remission (time and percentage of achieving remission). Timepoint: 2nd, 4th, 6th, 8th, 18th, 34th week. Method of measurement: clinical with physical exam and also ESR.